醛固酮对蟾蜍膀胱上皮细胞中3':5'-环磷酸腺苷在血管加压素和茶碱作用下积累的影响。
The effect of aldosterone on the accumulation of adenosine 3':5'-cyclic monophosphate in toad bladder epithelial cells in response to vasopressin and theophylline.
作者信息
Stoff J S, Handler J S, Orloff J
出版信息
Proc Natl Acad Sci U S A. 1972 Apr;69(4):805-8. doi: 10.1073/pnas.69.4.805.
Abstract
Vasopressin and theophylline both increase the content of adenosine 3':5'-cyclic monophosphate (cAMP) in epithelial cells of the urinary bladder of toads (Bufo marinus). Incubation of the tissue with 0.2 muM aldosterone markedly increases this response to the two agents; incubation for a similar time without steroid reduces the response. The permeability responses (sodium transport and water flow) of the intact tissue to vasopressin, theophylline, and exogenous cAMP are also considerably greater in bladders incubated with aldosterone than without. The results are interpreted as indicating that the foregoing permissive effects of aldosterone on the permeability responses to vasopressin and theophylline are mediated by a steroid-dependent increase in the accumulation of cAMP in the pertinent epithelial cells, probably as a consequence of a diminution in the rate of degradation of the intracellular nucleotide.
摘要
血管加压素和茶碱均可增加蟾蜍（海蟾蜍）膀胱上皮细胞中3':5'-环磷酸腺苷（cAMP）的含量。用0.2μM醛固酮孵育组织可显著增强对这两种药物的反应；在无类固醇的情况下进行类似时间的孵育则会降低反应。与未用醛固酮孵育的膀胱相比，用醛固酮孵育的完整组织对血管加压素、茶碱和外源性cAMP的通透性反应（钠转运和水流）也明显更强。这些结果被解释为表明，醛固酮对血管加压素和茶碱通透性反应的上述允许作用是由相关上皮细胞中cAMP积累的类固醇依赖性增加介导的，这可能是细胞内核苷酸降解速率降低的结果。
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The effect of aldosterone on the accumulation of adenosine 3':5'-cyclic monophosphate in toad bladder epithelial cells in response to vasopressin and theophylline.醛固酮对蟾蜍膀胱上皮细胞中3':5'-环磷酸腺苷在血管加压素和茶碱作用下积累的影响。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The similarity of effects of vasopressin, adenosine-3',5'-phosphate (cyclic AMP) and theophylline on the toad bladder.血管加压素、腺苷 - 3',5'-磷酸（环磷酸腺苷）和茶碱对蟾蜍膀胱作用的相似性。
J Clin Invest. 1962 Apr;41(4):702-9. doi: 10.1172/JCI104528.
3
Stimulation of active sodium transport by the isolated toad bladder with aldosterone in vitro.体外醛固酮对离体蟾蜍膀胱主动钠转运的刺激作用。
J Clin Invest. 1961 Nov;40(11):2103-10. doi: 10.1172/JCI104436.
4
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
5
6
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7
The role of adenosine 3',5'-phosphate in the action of antidiuretic hormone.3',5'-磷酸腺苷在抗利尿激素作用中的角色。
Am J Med. 1967 May;42(5):757-68. doi: 10.1016/0002-9343(67)90093-9.
8
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9
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J Biol Chem. 1971 May 10;246(9):2859-69.
10
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Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
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