Cohen I S, Wharton T P, Neill W A
Am Heart J. 1979 Jun;97(6):766-72. doi: 10.1016/0002-8703(79)90013-9.
The use of a simple technique for multiplane echocardiographic analysis and study of the effect of arrhythmia enabled us to investigate the mechanism of premature opening of the aortic valve in two patients with subacute aortic insufficiency. In one patient, premature opening evolved with the development of left ventricular dilatation and failure. In this case the prematurity of opening in each beat was related to diastolic filling time and was accompanied by septal recoil and by premature closure of the mitral valve. We classified this as the diastolic duration-dependent subgroup. In the second patient, who had a hypertrophied, non-dilated left ventricle, premature opening depended on atrial contraction and was independent of diastolic filling time. This case defined an atrial contraction-dependent subgroup. In the light of these findings we analyzed previously reported cases in patients with acute severe aortic insufficiency. These patients appear to fall into the diastolic duration-dependent subgroup.
采用一种简单的多平面超声心动图分析技术并研究心律失常的影响，使我们能够对两名亚急性主动脉瓣关闭不全患者主动脉瓣过早开放的机制进行研究。在一名患者中，过早开放随着左心室扩张和衰竭的发展而出现。在这种情况下，每次心跳开放的提前期与舒张期充盈时间有关，并伴有室间隔回弹和二尖瓣过早关闭。我们将此归类为舒张期持续时间依赖型亚组。在第二名患者中，其左心室肥厚但未扩张，过早开放取决于心房收缩，且与舒张期充盈时间无关。该病例定义了一个心房收缩依赖型亚组。根据这些发现，我们分析了先前报道的急性严重主动脉瓣关闭不全患者的病例。这些患者似乎属于舒张期持续时间依赖型亚组。
