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Interferon administered orally: protection of neonatal mice from lethal virus challenge.

作者信息

Schafer T W, Lieberman M, Cohen M, Came P E

出版信息

Science. 1972 Jun 23;176(4041):1326-7. doi: 10.1126/science.176.4041.1326.

DOI:10.1126/science.176.4041.1326
PMID:4338344
Abstract

Interferon was identified in the milk of mice injected with an interferon inducer. The kinetics of interferon appearance in serum and in milk were similar, but maximum concentrations in milk were 10 to 20 percent of those in serum. Interferon administered orally to neonatal mice was detected in their serums. Significantly more newborns survived an oral challenge with vesicular stomatitis virus when interferon had been induced in the lactating mothers.

摘要

相似文献

1
Interferon administered orally: protection of neonatal mice from lethal virus challenge.
Science. 1972 Jun 23;176(4041):1326-7. doi: 10.1126/science.176.4041.1326.
2
Mediators of protection against lethal systemic vesicular stomatitis virus infection in hamsters: defective interfering particles, polyinosinate-polycytidylate, and interferon.仓鼠抵抗致死性系统性水疱性口炎病毒感染的保护介质:缺陷干扰颗粒、聚肌苷酸-聚胞苷酸和干扰素。
Infect Immun. 1982 Aug;37(2):679-86. doi: 10.1128/iai.37.2.679-686.1982.
3
Protective effect of interferon and polyacrylic acid in newborn mice infected with a lethal dose of vesicular stomatitis virus.
Life Sci. 1968 Sep 1;7(17):925-33. doi: 10.1016/0024-3205(68)90098-2.
4
The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice.干扰素在合成双链多聚核糖核苷酸对小鼠鼻内接种水泡性口炎病毒攻击的保护作用中的角色。
J Clin Invest. 1970 Aug;49(8):1565-77. doi: 10.1172/JCI106374.
5
Role of spleen in production of virus induced interferon in rabbits. Brief report.
Arch Gesamte Virusforsch. 1972;39(4):396-400. doi: 10.1007/BF01241021.
6
Effect of administered interferon on rabies in rabbits.给予干扰素对家兔狂犬病的影响。
Appl Microbiol. 1971 Sep;22(3):428-31. doi: 10.1128/am.22.3.428-431.1971.
7
Stimulation or inhibition of interferon production depending on time of cycloheximide administration.根据放线菌酮给药时间的不同,干扰素的产生会受到刺激或抑制。
Virology. 1970 Nov;42(3):799-802. doi: 10.1016/0042-6822(70)90328-4.
8
Interferon clearance rate decreased after repeated injections.
J Gen Virol. 1971 Aug;12(2):191-4. doi: 10.1099/0022-1317-12-2-191.
9
[Cellular origin or rabbit serum interferon induced by Newcastle disease virus].[新城疫病毒诱导的兔血清干扰素的细胞起源]
Arch Gesamte Virusforsch. 1973;40(3):334-40.
10
Interferon production and infection caused by vesicular stomatitis virus in radiation chimeras.辐射嵌合体中水泡性口炎病毒引起的干扰素产生及感染
Acta Virol. 1973 Mar;17(2):159-62.

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5
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Effect of thymopentin on the mortality and immune response after an experimental herpes simplex infection in mice.胸腺五肽对小鼠实验性单纯疱疹病毒感染后死亡率及免疫反应的影响。
Surv Immunol Res. 1985;4 Suppl 1:48-57. doi: 10.1007/BF02919056.
7
The effect of interferon induction in parturient sows and newborn piglets on resistance to transmissible gastroenteritis.分娩母猪和新生仔猪中干扰素诱导对抵抗传染性胃肠炎的影响。
Can J Vet Res. 1988 Jan;52(1):149-53.
8
Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Does an unorthodox route improve the therapeutic index of interferon?
Clin Pharmacokinet. 1991 Dec;21(6):411-7. doi: 10.2165/00003088-199121060-00002.