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1
Selective inhibition by glycine of some somatic reflexes in the cat.甘氨酸对猫某些躯体反射的选择性抑制作用。
Br J Pharmacol. 1972 Mar;44(3):404-12. doi: 10.1111/j.1476-5381.1972.tb07279.x.
2
NONSPECIFIC DEPRESSANT ACTION OF GAMMA-AMINOBUTYRIC ACID ON SOMATIC REFLEXES.γ-氨基丁酸对躯体反射的非特异性抑制作用。
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Strychnine-sensitive inhibition in the medullary reticular formation: evidence for glycine as an inhibitory transmitter.延髓网状结构中士的宁敏感抑制作用:甘氨酸作为抑制性递质的证据。
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The action of para-methoxyphenylethylamine (PMPEA) on monosynaptic reflex transmission in the cat.对甲氧基苯乙胺(PMPEA)对猫单突触反射传递的作用。
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本文引用的文献

1
Effects of intrathecal injection of KCl and other solutions in cats. Excitatory action of K ions on posterior nerve root fibres.鞘内注射氯化钾及其他溶液对猫的影响。钾离子对后神经根纤维的兴奋作用。
J Physiol. 1947 Jun 2;106(2):211-35.
2
A neuropharmacological study on the effect of myanesin (tolserol) on motor systems.关于美乃星(托司罗尔)对运动系统影响的神经药理学研究。
J Pharmacol Exp Ther. 1949 Nov;97(3):331-41.
3
NONSPECIFIC DEPRESSANT ACTION OF GAMMA-AMINOBUTYRIC ACID ON SOMATIC REFLEXES.γ-氨基丁酸对躯体反射的非特异性抑制作用。
Br J Pharmacol Chemother. 1964 Oct;23(2):391-8. doi: 10.1111/j.1476-5381.1964.tb01595.x.
4
Effects of central nervous system depressants on inhibition and facilitation of the patellar reflex.中枢神经系统抑制剂对髌反射抑制和易化的影响。
Arch Int Pharmacodyn Ther. 1960 Oct 1;128:169-86.
5
The action of mephenesin and other interneuron depressants on the brain stem.甲酚甘油醚及其他中间神经元抑制剂对脑干的作用。
J Pharmacol Exp Ther. 1954 Jul;111(3):293-301.
6
Injections of drugs into the lateral ventricle of the cat.将药物注射到猫的侧脑室。
J Physiol. 1954 Jan;123(1):148-67. doi: 10.1113/jphysiol.1954.sp005040.
7
The distribution of glycine in cat spinal cord and roots.甘氨酸在猫脊髓和神经根中的分布。
Life Sci. 1965 Nov;4(21):2075-83. doi: 10.1016/0024-3205(65)90325-5.
8
A pharmacological study of the depression of spinal neurones by glycine and related amino acids.甘氨酸及相关氨基酸对脊髓神经元抑制作用的药理学研究。
Exp Brain Res. 1968;6(1):1-18. doi: 10.1007/BF00235443.
9
The hyperpolarization of spinal motoneurones by glycine and related amino acids.甘氨酸及相关氨基酸对脊髓运动神经元的超极化作用。
Exp Brain Res. 1968;5(3):235-58. doi: 10.1007/BF00238666.
10
The pharmacology of amino acids related to gamma-aminobutyric acid.与γ-氨基丁酸相关的氨基酸药理学
Pharmacol Rev. 1965 Dec;17(4):347-91.

甘氨酸对猫某些躯体反射的选择性抑制作用。

Selective inhibition by glycine of some somatic reflexes in the cat.

作者信息

Dhawan B N, Sharma J N, Srimal R C

出版信息

Br J Pharmacol. 1972 Mar;44(3):404-12. doi: 10.1111/j.1476-5381.1972.tb07279.x.

DOI:10.1111/j.1476-5381.1972.tb07279.x
PMID:4339248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665829/
Abstract
  1. The effects of intracerebroventricular or intrathecal administration of glycine on some somatic reflexes in chloralosed cats were investigated.2. Glycine produced marked inhibition of the flexor reflex (FR) and crossed extensor reflex (CER) at low doses (2.5-5.0 mg) but even large doses (up to 40.0 mg) had no effect on the facilitation or inhibition of the patellar reflex produced by stimulation of either the reticular formation or the sciatic nerve. The linguomandibular reflex (LMR) could be blocked by 10-20 mg glycine.3. Glycine antagonized strychnine-induced facilitation of FR, CER and LMR and was 5-6 times as active as gamma-aminobutyric acid in this respect.4. The possibility of glycine being a transmitter in spinal pathways is discussed.
摘要
  1. 研究了脑室内或鞘内注射甘氨酸对水合氯醛麻醉猫某些躯体反射的影响。

  2. 低剂量(2.5 - 5.0毫克)的甘氨酸可显著抑制屈肌反射(FR)和交叉伸肌反射(CER),但即使大剂量(高达40.0毫克)对刺激网状结构或坐骨神经所产生的髌反射的易化或抑制也无影响。舌下颌反射(LMR)可被10 - 20毫克甘氨酸阻断。

  3. 甘氨酸拮抗士的宁诱导的FR、CER和LMR的易化作用,在这方面其活性是γ-氨基丁酸的5 - 6倍。

  4. 讨论了甘氨酸作为脊髓通路中递质的可能性。