甘氨酸对猫某些躯体反射的选择性抑制作用。
Selective inhibition by glycine of some somatic reflexes in the cat.
作者信息
Dhawan B N, Sharma J N, Srimal R C
出版信息
Br J Pharmacol. 1972 Mar;44(3):404-12. doi: 10.1111/j.1476-5381.1972.tb07279.x.
Abstract
- The effects of intracerebroventricular or intrathecal administration of glycine on some somatic reflexes in chloralosed cats were investigated.2. Glycine produced marked inhibition of the flexor reflex (FR) and crossed extensor reflex (CER) at low doses (2.5-5.0 mg) but even large doses (up to 40.0 mg) had no effect on the facilitation or inhibition of the patellar reflex produced by stimulation of either the reticular formation or the sciatic nerve. The linguomandibular reflex (LMR) could be blocked by 10-20 mg glycine.3. Glycine antagonized strychnine-induced facilitation of FR, CER and LMR and was 5-6 times as active as gamma-aminobutyric acid in this respect.4. The possibility of glycine being a transmitter in spinal pathways is discussed.
摘要
研究了脑室内或鞘内注射甘氨酸对水合氯醛麻醉猫某些躯体反射的影响。
低剂量（2.5 - 5.0毫克）的甘氨酸可显著抑制屈肌反射（FR）和交叉伸肌反射（CER），但即使大剂量（高达40.0毫克）对刺激网状结构或坐骨神经所产生的髌反射的易化或抑制也无影响。舌下颌反射（LMR）可被10 - 20毫克甘氨酸阻断。
甘氨酸拮抗士的宁诱导的FR、CER和LMR的易化作用，在这方面其活性是γ-氨基丁酸的5 - 6倍。
讨论了甘氨酸作为脊髓通路中递质的可能性。
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