纤溶酶对血管紧张素II的降解作用。
Degradation of angiotensin II by plasmin.
作者信息
Dudek G, Latallo Z S, Prokopowicz J, Worowski K
出版信息
Br J Pharmacol. 1972 May;45(1):60-3. doi: 10.1111/j.1476-5381.1972.tb09576.x.
Abstract
- Synthetic angiotensin II (Hypertensin, Ciba, Basel) was incubated with a water-insoluble preparation of plasmin (E.C. 3.4.4.14) and the resulting products analysed by paper chromatography and N-terminal amino-acid analysis.2. Only the N-terminal asparagine was split off from the peptide. This indicates that plasmin attacks the Asn-Arg but not the Arg-Val in angiotensin II molecule.
摘要
将合成的血管紧张素II（高血压素，汽巴公司，巴塞尔）与一种水不溶性的纤溶酶制剂（E.C. 3.4.4.14）一起温育，并用纸色谱法和N端氨基酸分析法对所得产物进行分析。
只有N端的天冬酰胺从该肽中被裂解下来。这表明纤溶酶作用于血管紧张素II分子中的天冬酰胺-精氨酸键，而不是精氨酸-缬氨酸键。
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本文引用的文献
1
Partial purification and properties of a proteolytic enzyme of human serum.人血清中一种蛋白水解酶的部分纯化及性质
J Biol Chem. 1949 Nov;181(1):431-48.
2
The activation of human plasminogen by streptokinase.链激酶对人纤溶酶原的激活作用。
J Biol Chem. 1955 Apr;213(2):881-91.
3
ANTIGENS AND ENZYMES MADE INSOLUBLE BY ENTRAPPING THEM INTO LATTICES OF SYNTHETIC POLYMERS.通过将抗原和酶包埋于合成聚合物晶格中使其不溶。
Science. 1963 Nov 8;142(3593):678-9. doi: 10.1126/science.142.3593.678.
4
Angiotensinase with a high degree of specificity in plasma and red cells.
Science. 1963 May 10;140(3567):672-4. doi: 10.1126/science.140.3567.672.
5
A mammalian peptidase specific for the hydrolysis of N-terminal alpha-L-glutamyl and aspartyl residues.一种特异性水解N端α-L-谷氨酰基和天冬氨酰基残基的哺乳动物肽酶。
Nature. 1962 Jun 2;194:867. doi: 10.1038/194867a0.
6
Fibrinolytic system in the dog with experimental renal (Goldblatt) hypertension.实验性肾性（戈德布拉特）高血压犬的纤溶系统
Experientia. 1967 Mar 15;23(3):224-5. doi: 10.1007/BF02136302.
7
Thin-layer chromatographic separation of DNS-amino acids.DNS-氨基酸的薄层色谱分离
Anal Biochem. 1966 Mar;14(3):429-33. doi: 10.1016/0003-2697(66)90285-5.
8
Purification and properties of endopeptidase from rabbit red cells and its process of degradation of angiotensin.兔红细胞内肽酶的纯化、性质及其对血管紧张素的降解过程
Biochim Biophys Acta. 1969;191(3):668-76. doi: 10.1016/0005-2744(69)90360-x.
9
Partial inactivation of angiotensin II by plasmin.纤溶酶对血管紧张素II的部分失活作用。
Thromb Diath Haemorrh. 1969 Feb 28;21(1):166-7.
10
New enzymatic route for the inactivation of angiotensin.使血管紧张素失活的新酶促途径。
Nature. 1968 Jun 29;218(5148):1224-6. doi: 10.1038/2181224a0.
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