心肌环磷酸腺苷浓度与拟交感神经胺类药物的变力作用之间缺乏相关性。
Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines.
作者信息
Benfey B G
出版信息
Br J Pharmacol. 1971 Dec;43(4):757-63. doi: 10.1111/j.1476-5381.1971.tb07211.x.
Abstract
- Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.
摘要
对能增强离体心脏收缩性的拟交感胺进行了测试，以观察其对兔心脏切片中环磷酸腺苷（cAMP）浓度及兔心脏匀浆中腺苷酸环化酶活性的影响。
正如预期的那样，去甲肾上腺素刺激了腺苷酸环化酶活性并增加了环磷酸腺苷浓度，但多巴胺和去氧肾上腺素无效。
这一结果不支持环磷酸腺苷在拟交感胺的正性肌力作用中起关键作用这一概念。
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Br J Pharmacol. 1971 Dec;43(4):757-63. doi: 10.1111/j.1476-5381.1971.tb07211.x.
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