Weiss H, Annesley W H, Shields J A, Tomer T, Christopherson K
Am J Ophthalmol. 1979 Feb;87(2):133-42. doi: 10.1016/0002-9394(79)90131-4.
We closely observed nine patients (17 eyes) with serpiginous choroidopathy for time periods ranging from two to ten years. There were seven men and two women with ages ranging from 22 to 58 years, average age was 46 years. Eight patients were bilaterally affected; one patient had only one eye. The clinical course of the disease was characterized by multiple recurrences. The recurrences and progression of the disease often were not noticed by patients if the macular area was not involved. Serial fundus photographs proved to be invaluable in establishing progression. Although the disease usually progresses in a centrifugal manner from the disk toward the periphery, three patients demonstrated centripetal progression and one of these three permanently lost central acuity. Visual acuity was affected only when the foveal or parafoveal areas became involved, but in nine of the 17 eyes, visual acuity returned to a variable degree. None of the patients had any general systemic illness. However, five of the patients reported chronic exposure to an unusual variety of chemicals.
我们对9例（17只眼）匐行性脉络膜病变患者进行了为期2至10年的密切观察。其中男性7例，女性2例，年龄在22至58岁之间，平均年龄46岁。8例患者双眼受累；1例患者仅单眼患病。该疾病的临床病程以多次复发为特征。如果黄斑区未受累，疾病的复发和进展通常不易被患者察觉。连续的眼底照片在确定病情进展方面被证明具有极高价值。尽管该疾病通常以离心方式从视盘向周边进展，但有3例患者表现为向心性进展，其中1例永久性丧失中心视力。仅当黄斑中心凹或旁中心凹区域受累时视力才会受到影响，但在17只眼中有9只眼的视力不同程度恢复。所有患者均无全身性疾病。然而，5例患者报告长期接触多种特殊化学品。
