Csiza C K, de Lahunta A
Am J Pathol. 1979 Apr;95(1):215-24.
Myelin deficiency (md), a newly discovered neurologic mutation in the Wistar rat, is transmitted by an X-linked, recessive lethal gene. Male rats are affected, and the first symptom is a head tremor recognizable at 12 to 15 days of age. The tremors become generalized within a few days and disappear when the animal is at rest. In the later stages, from 17 to 21 days of age, the slightest disturbance will precipitate a generalized seizure. Pups die within 30 days after birth. The only gross postmortem change is a gray color of the spinal cord instead of its normally white appearance. Microscopic findings reveal total lack of myelin formation at all levels of the central nervous system.
髓磷脂缺乏症（md）是在Wistar大鼠中新发现的一种神经学突变，由X连锁隐性致死基因传递。雄性大鼠受影响，首个症状是在12至15日龄时可识别的头部震颤。震颤在几天内变得全身性，动物休息时消失。在后期，即17至21日龄时，最轻微的干扰都会引发全身性癫痫发作。幼崽在出生后30天内死亡。唯一明显的死后变化是脊髓呈灰色而非正常的白色外观。显微镜检查结果显示中枢神经系统所有层面完全缺乏髓磷脂形成。
