含有视紫红质的磷脂双层膜的制备与性质
Preparation and properties of phospholipid bilayers containing rhodopsin.
作者信息
Hong K, Hubbell W L
出版信息
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2617-21. doi: 10.1073/pnas.69.9.2617.
Abstract
Purified rhodopsin has been prepared containing less than 1.1 mol of phosphate per mol of protein. The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines. Rhodopsin appears to inhibit segmental motions of the hydrocarbon chains, an effect similar to that of cholesterol on phospholipid bilayers.
摘要
已制备出每摩尔蛋白质含磷量低于1.1摩尔的纯化视紫红质。纯化后的视紫红质已被整合到磷脂酰胆碱双层膜中，并通过使用自旋标记的磷脂酰胆碱来研究双层膜内的分子相互作用。视紫红质似乎会抑制烃链的片段运动，这种效应与胆固醇对磷脂双层膜的效应相似。
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