Kaye M P, Wells D J, Tyce G M
Am J Physiol. 1979 Apr;236(4):H624-8. doi: 10.1152/ajpheart.1979.236.4.H624.
Nerve growth factor (NGF) was administered in doses of 25,000 U daily for the first 5 postoperative days to dogs subjected to cardiac denervation. These dogs and untreated cardiac-denervated dogs were killed at 1, 2, 3, and 6 mo postoperatively. Tritiated norepinephrine ([3H]NE) was administered prior to death, after which the hearts were removed and eight segments (right and left atria, right ventricular conus and sinus, left ventricular base and apex and high and low ventricular septum) analyzed to determine myocardial NE content and uptake of [3H]NE. Our data demonstrated enhanced cardiac reinnervation of the left ventricular base in NGF-treated dogs.
对接受心脏去神经支配的犬，在术后头5天每天给予剂量为25,000单位的神经生长因子（NGF）。这些犬以及未接受治疗的心脏去神经支配犬在术后1、2、3和6个月处死。在处死前给予氚标记的去甲肾上腺素（[3H]NE），之后取出心脏，分析八个节段（右心房和左心房、右心室圆锥和窦部、左心室基部和心尖以及高和低室间隔）以确定心肌去甲肾上腺素含量和[3H]NE摄取情况。我们的数据表明，接受NGF治疗的犬左心室基部的心脏再神经支配增强。
