Gorsky B H, Cascorbi H F
Anesthesiology. 1979 Feb;50(2):123-5. doi: 10.1097/00000542-197902000-00009.
Other investigators have demonstrated halothane-induced hepatic injury in rats anesthetized in hypoxic environments. The authors examined this phenomenon in mice and investigated plasma fluoride levels in mice and rats anesthetized with halothane in 40, 21 and 7 per cent oxygen with or without pretreatment with phenobarbital or carbon tetrachloride. They found no hepatic necrosis in mice. Mice produced less fluoride than rats. This difference in halothane metabolism between Sprague-Dawley rats and Swiss-Webster mice may explain the failure to observe hepatic necrosis in mice.
其他研究人员已证实在缺氧环境中麻醉的大鼠会出现氟烷诱导的肝损伤。作者在小鼠中研究了这一现象，并调查了在40%、21%和7%氧气环境中用氟烷麻醉的小鼠和大鼠的血浆氟水平，这些动物有或没有用苯巴比妥或四氯化碳预处理。他们在小鼠中未发现肝坏死。小鼠产生的氟比大鼠少。斯普拉格-道利大鼠和瑞士韦伯斯特小鼠在氟烷代谢上的这种差异可能解释了在小鼠中未观察到肝坏死的原因。
