Blitt C D, Raessler K L, Wightman M A, Groves B M, Wall C L, Geha D G
Anesthesiology. 1979 Mar;50(3):210-2. doi: 10.1097/00000542-197903000-00008.
The effects of 1.25, 2.0, and 2.5 MAC isoflurane on atrioventricular conduction were studied by His-bindle electrocardiography during atrial pacing in ten dogs. No effect upon atrioventricular conduction as evidenced by changes in A--H interval (the time of conduction from low right atrium to His-bundle, representing primary AV nodal conduction) was found at these concentrations. Atrial pacing to 200 beats/min did not influence the A--H interval at the three anesthetic concentrations. The stability of cardiac rhythm observed clinically with isoflurane may be related to this lack of effect upon the AV node.
在十只犬心房起搏期间，通过希氏束心电图研究了1.25、2.0和2.5最低肺泡有效浓度（MAC）异氟烷对房室传导的影响。在这些浓度下，未发现A-H间期（从右心房下部传导至希氏束的时间，代表主要房室结传导）变化所证实的对房室传导的影响。在三种麻醉浓度下，心房起搏至200次/分钟并未影响A-H间期。临床上观察到的异氟烷所致心律稳定性可能与此对房室结缺乏影响有关。
