Rosenberg H
Anesthesiology. 1979 Apr;50(4):331-5. doi: 10.1097/00000542-197904000-00009.
In isolated rat diaphragm strips, halothane augments the tension produced during caffeine-induced contractures in a dose-related manner. Potassium-induced contracture tension is augmented in the presence of halothane to a concentration of 0.75 per cent, and decreased at halothane concentrations of more than 1 per cent. The time of peak tension for potassium-induced contractures is diminished by all halothane concentrations. T-tubular disruption by hypertonic glycerol does not alter anesthetic-induced augmentation of caffeine-induced contractures. It is postulated that halothane augments calcium-release processes in sarcoplasmic reticulum. Membrane events or excitation-contraction coupling steps may be also altered by halothane.
在离体大鼠膈肌条中，氟烷以剂量相关的方式增强咖啡因诱导挛缩期间产生的张力。在氟烷存在下，钾诱导的挛缩张力在浓度为0.75%时增强，而在氟烷浓度超过1%时降低。所有氟烷浓度均可缩短钾诱导挛缩的张力峰值时间。高渗甘油引起的T小管破坏并不改变麻醉药诱导的咖啡因诱导挛缩的增强作用。据推测，氟烷增强了肌浆网中的钙释放过程。氟烷也可能改变膜事件或兴奋-收缩偶联步骤。
