3'-5'-环磷酸腺苷对细胞增殖的影响。
Effect of adenosine 3'-5'-cyclic monophosphate on cell proliferation.
作者信息
Froehlich J E, Rachmeler M
出版信息
J Cell Biol. 1972 Oct;55(1):19-31. doi: 10.1083/jcb.55.1.19.
Abstract
Secondary cultures of human diploid fibroblasts, which demonstrate density-dependent inhibition of cell growth, were used to study the effect of adenosine 3'-5'-cyclic monophosphate (cAMP) on cell proliferation. DNA synthesis in nonconfluent cultures and in contact-inhibited cultures stimulated to grow by refeeding with fresh medium was found to be inhibited by exogenous cAMP. The properties of this inhibition of DNA synthesis, together with the alterations in cAMP metabolism observed in confluent cultures of cells stimulated with fresh medium to resume growth, strongly suggest that cAMP is involved in contact-inhibition of cell proliferation.
摘要
人类二倍体成纤维细胞的传代培养物表现出细胞生长的密度依赖性抑制，利用该传代培养物研究了3'-5'-环磷酸腺苷（cAMP）对细胞增殖的影响。结果发现，在未汇合培养物以及通过补充新鲜培养基刺激生长的接触抑制培养物中，DNA合成受到外源性cAMP的抑制。这种对DNA合成的抑制特性，连同在用新鲜培养基刺激以恢复生长的汇合细胞培养物中观察到的cAMP代谢变化，强烈表明cAMP参与细胞增殖的接触抑制。
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