用α-肾上腺素能阻断药使豚鼠回肠场刺激诱发的乙酰胆碱释放增加。
Increase by alpha-adrenolytic drugs of acetylcholine release evoked by field stimulation of the guinea-pig ileum.
作者信息
Kilbinger H, Wessler I
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1979 Nov;309(3):255-7. doi: 10.1007/BF00504758.
PMID:43477
Abstract
The release of acetylcholine evoked by field stimulation of the guinea-pig ileum (3 Hz) is increased by yohimbine and tolazoline but not affected by phentolamine. It is proposed that yohimbine and tolazoline by blocking alpha-adrenoceptors of the cholinergic nerves abolish the inhibition caused by endogenous noradrenaline, and thus facilitate the output of acetylcholine.
摘要
豚鼠回肠（3赫兹）场刺激诱发的乙酰胆碱释放量，在育亨宾和妥拉唑啉作用下增加，但不受酚妥拉明影响。有人提出，育亨宾和妥拉唑啉通过阻断胆碱能神经的α-肾上腺素能受体，消除内源性去甲肾上腺素引起的抑制作用，从而促进乙酰胆碱的释放。
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