某些磷酸二酯酶抑制剂对水合氯醛麻醉猫的灌注血管床传导性的影响。
The effects of some phosphodiesterase inhibitors on the conductance of the perfused vascular beds of the chloralosed cat.
作者信息
Hamilton T C
出版信息
Br J Pharmacol. 1972 Nov;46(3):386-94. doi: 10.1111/j.1476-5381.1972.tb08135.x.
Abstract
- The vasoactivity of a number of phosphodiesterase inhibitors in the auto-perfused splanchnic region and hindquarters of the cat have been investigated.2. Theophylline, dipyridamole and 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956) and its analogues were more potent vasodilators in the splanchnic region than in the hindquarters, whereas papaverine was a potent vasodilator in both these vascular beds.3. The vasodilator response to the phosphodiesterase inhibitors in the splanchnic region and hindquarters was not susceptible to beta-adrenoceptor blockade.4. Infusion of dibutyryl cyclic AMP into the superior mesenteric artery increased vascular conductance of the splanchnic region. This effect was enhanced by Ro 20-1724 in doses below those in which this compound affected conductance.5. These results are consistent with the hypothesis that accumulation of cyclic AMP in vascular smooth muscle mediates the vasodilator response to phosphodiesterase inhibitors.
摘要
对多种磷酸二酯酶抑制剂在猫的自体灌注内脏区域和后肢的血管活性进行了研究。
茶碱、双嘧达莫、4-(3,4-二甲氧基苄基)-2-咪唑啉酮（Ro 7-2956）及其类似物在内脏区域比在后肢是更强效的血管扩张剂，而罂粟碱在这两个血管床中都是强效血管扩张剂。
在内脏区域和后肢，对磷酸二酯酶抑制剂的血管扩张反应不易受到β-肾上腺素能受体阻断的影响。
向上肠系膜动脉内输注二丁酰环磷腺苷可增加内脏区域的血管传导性。低于该化合物影响传导的剂量时，Ro 20-1724可增强这种效应。
这些结果与环磷腺苷在血管平滑肌中的蓄积介导对磷酸二酯酶抑制剂的血管扩张反应这一假说一致。
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