慢性黏膜皮肤念珠菌病。口服间歇剂量克霉唑治疗成功。

Chronic mucocutaneous candidiasis. Successful treatment with intermittent oral doses of clotrimazole.

作者信息

Rockoff A S

出版信息

Arch Dermatol. 1979 Mar;115(3):322-3. doi: 10.1001/archderm.115.3.322.

DOI:10.1001/archderm.115.3.322

Abstract

Treatment of chronic mucocutaneous candidiasis has included drugs, immunotherapy, and replacement of nutritional and endocrine deficiency. Although amphotericin B is the best known and most commonly used form of treatment, the imidazole antibiotic clotrimazole has shown promise as an effective agent that can be given orally with low toxicity. A 9-year-old girl responded to intermittent clotrimazole therapy with complete and prolonged remission. This form of treatment offers advantages in safety and effectiveness over other therapies for chronic mucocutaneous candidiasis.

摘要

慢性黏膜皮肤念珠菌病的治疗方法包括药物治疗、免疫疗法以及补充营养和内分泌缺乏。虽然两性霉素B是最广为人知且最常用的治疗形式，但咪唑类抗生素克霉唑已显示出有望成为一种有效药物，它可以口服且毒性较低。一名9岁女孩接受间歇性克霉唑治疗后实现了完全且持久的缓解。这种治疗形式在安全性和有效性方面优于慢性黏膜皮肤念珠菌病的其他治疗方法。