性别和膳食钙对大鼠肠道镉吸收的影响。

Influence of sex and dietary calcium on intestinal cadmium absorption in rats.

作者信息

Kello D, Dekanić D, Kostial K

出版信息

Arch Environ Health. 1979 Jan-Feb;34(1):30-3. doi: 10.1080/00039896.1979.10667363.

DOI:10.1080/00039896.1979.10667363

Abstract

The influence of sex and dietary calcium on whole-body retention of orally administered 115mCdCl2 has a half-life of 43 days, distinguishing it from 115Cd of half-life 2.3 days was studied in one-year-old control and gonadectomized male and female rats. Gonadectomy was performed at the age of four months. Each of the four experimental groups was divided into three subgroups that were fed rat food with a different calcium content (2.4, 0.7, and 0.3% Ca) throughout the experiment. Regardless of sex and gonadectomy the mean percent values of 115mCd retention in the whole body decreased with increasing dietary calcium level. Male rats retained less cadmium than all other experimental groups of animals. These data clearly point out that sex and diet might influence the level of ingested cadmium in the body.

摘要

研究了性别和膳食钙对口服115mCdCl2全身潴留的影响，其半衰期为43天，这使其与半衰期为2.3天的115Cd有所区别。实验对象为一岁的对照大鼠以及去势的雄性和雌性大鼠。在四个月大时进行去势手术。四个实验组中的每组又分为三个亚组，在整个实验过程中分别喂食钙含量不同（2.4%、0.7%和0.3%钙）的大鼠食物。无论性别和去势情况如何，全身115mCd潴留的平均百分比值均随着膳食钙水平的升高而降低。雄性大鼠体内镉的潴留量低于所有其他实验组动物。这些数据清楚地表明，性别和饮食可能会影响体内摄入镉的水平。