Beart P M, McDonald D, Gundlach A L
Neurosci Lett. 1979 Dec;15(2-3):165-70. doi: 10.1016/0304-3940(79)96107-x.
The concept that a neurone may release transmitter from both dendritic and axonal sites was investigated by studying mesolimbic dopaminergic neurones. The rat ventral tegmentum (containing dendrites and somata of mesolimbic dopaminergic neurones) possessed high levels of dopamine and tyrosine hydroxylase. Slices of ventral tegmentum accumulated [3H]dopamine (15 or 60 nM) and stimulus-induced release of [3H]dopamine was observed after elevated potassium (44 mM). The potassium-induced release was calcium-dependent. These dopaminergic parameters were compared to those found for nucleus accumbens (containing terminals of mesolimbic dopaminergics neurones). Thioridazine and clozapine elevated 3,4-dihydroxyphenylacetic acid (DOPAC) concentration in ventral tegmentum.
通过研究中脑边缘多巴胺能神经元，对神经元可能从树突和轴突部位释放递质这一概念进行了研究。大鼠腹侧被盖区（包含中脑边缘多巴胺能神经元的树突和胞体）含有高水平的多巴胺和酪氨酸羟化酶。腹侧被盖区切片积累了[3H]多巴胺（15或60 nM），在高钾（44 mM）后观察到刺激诱导的[3H]多巴胺释放。钾诱导的释放是钙依赖性的。将这些多巴胺能参数与伏隔核（包含中脑边缘多巴胺能神经元的终末）的参数进行了比较。硫利达嗪和氯氮平提高了腹侧被盖区中3,4-二羟基苯乙酸（DOPAC）的浓度。
