传染性单核细胞增多症中的免疫球蛋白和EB病毒抗体
Immunoglobulins and EB virus antibodies in infectious mononucleosis.
作者信息
Sutton R N, Reynolds K, Almond J P, Marston S D, Emond R T
出版信息
Clin Exp Immunol. 1973 Mar;13(3):359-66.
Abstract
Antibodies to EB virus capsid, EB virus complement-fixing antibodies and IgM, IgA and IgG immunoglobulins were estimated in sera from seventy-four patients with infectious mononucleosis, eighty-nine control patients (mostly with infectious diseases) and 232 healthy medical students and nurses. Complement fixing (but not virus capsid) antibodies were much lower in patients tested during active infectious mononucleosis than in patients tested during late convalescence or in controls, a disparity which could form the basis of a diagnostic test. Immunoglobulin levels were higher in patients with active infectious mononucleosis than in controls and, when tested 6 months to 2 yr later, were still higher than those in healthy individuals.
摘要
对74例传染性单核细胞增多症患者、89例对照患者（大多患有传染病）以及232名健康医学生和护士的血清进行检测，以评估抗EB病毒衣壳抗体、EB病毒补体结合抗体以及IgM、IgA和IgG免疫球蛋白。在传染性单核细胞增多症急性期进行检测的患者中，补体结合抗体（而非病毒衣壳抗体）水平远低于恢复期后期检测的患者或对照，这种差异可作为诊断试验的基础。处于传染性单核细胞增多症急性期的患者免疫球蛋白水平高于对照，在6个月至2年后进行检测时，其水平仍高于健康个体。
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