Burke G, Chang L L, Szabo M
Science. 1973 May 25;180(4088):872-5. doi: 10.1126/science.180.4088.872.
Thyrotropin increases prostaglandin levels in isolated thyroid cells. Since comparable results were obtained with butyrated cyclic adenosine monophosphate derivatives as well as with the phosphodiesterase inhibitors quazodine and theophylline, it appears that cyclic adenosine monophosphate mediates this effect of thyrotropin. These observations suggest that intracellular prostaglandins play a role in modulating thyrotropin action on thyroid.
促甲状腺激素可提高分离的甲状腺细胞中的前列腺素水平。由于丁酰化环磷酸腺苷衍生物以及磷酸二酯酶抑制剂夸唑定和茶碱也得到了类似的结果，因此似乎环磷酸腺苷介导了促甲状腺激素的这一作用。这些观察结果表明，细胞内前列腺素在调节促甲状腺激素对甲状腺的作用中发挥作用。
