McComas A J, Sica R E, Upton A R, Aguilera N
J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):183-93. doi: 10.1136/jnnp.36.2.183.
Forty-six patients have been studied after upper motor neurone lesions of cerebrovascular origin. The numbers of functioning motor units in extensor digitorum brevis muscles were reduced to approximately half between the second and sixth months after a hemiplegic episode. The surviving motor units tended to have slow twitches and appeared to increase their sizes after the lesions had been present for about 20 months. The findings are explained on the basis of transsynaptic changes in alpha-motoneurones after degeneration of corticospinal fibres.
对46例脑血管源性上运动神经元损伤患者进行了研究。偏瘫发作后第二至六个月间，拇短伸肌中功能性运动单位的数量减少至大约一半。存活的运动单位往往具有慢肌纤维抽搐，并且在损伤出现约20个月后其大小似乎有所增加。这些发现是基于皮质脊髓纤维变性后α运动神经元的跨突触变化来解释的。
