大鼠下颌下腺的肾素样活性：特性以及几种药物和刺激因素的影响。
Renin-like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli.
作者信息
Gutman Y, Levy M, Shorr J
出版信息
Br J Pharmacol. 1973 Jan;47(1):59-68. doi: 10.1111/j.1476-5381.1973.tb08158.x.
Abstract
- Renin-like activity was found in rat submaxillary glands.2. This activity was destroyed by boiling, was non-dialyzable and showed an optimum at approximately 50 degrees C.3. Renin-like activity in the submaxillary gland was not diminished 24 h after nephrectomy but was considerably reduced after ligature of the submaxillary duct.4. Renin-like activity in the submaxillary gland was reduced following food-deprivation, water-deprivation or hypovolemia.5. Renin-like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine.6. Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy.7. Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity.
摘要
在大鼠下颌下腺中发现了肾素样活性。
这种活性经煮沸后被破坏，不可透析，且在约50摄氏度时表现出最佳活性。
肾切除术后24小时，下颌下腺中的肾素样活性并未降低，但下颌下腺导管结扎后则显著降低。
禁食、禁水或血容量减少后，下颌下腺中的肾素样活性降低。
给予异丙肾上腺素后，大鼠下颌下腺中的肾素样活性增加，但毛果芸香碱给药后则未增加。
给予氯化钠或氯化钾以及肾上腺切除术后，大鼠下颌下腺中的肾素样活性显著增加。
氯噻嗪和哇巴因增加了下颌下肾素样活性，但二氮嗪不影响该活性。
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