巴比妥酸盐诱导的青蛙神经肌肉接头处的递质释放。
Barbiturate-induced transmitter release at a frog neuromuscular junction.
作者信息
Thomson T D, Turkanis S A
出版信息
Br J Pharmacol. 1973 May;48(1):48-58. doi: 10.1111/j.1476-5381.1973.tb08221.x.
Abstract
- The influence of barbiturates on neuromuscular transmission at end-plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.2. Effects of a convulsant barbiturate, 5-(2-cyclohexylideneëthyl)-5-ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.3. CHEB and phenobarbitone increased the mean quantum content of the end-plate potentials and decreased the mean amplitude of the miniature end-plate potentials.4. Both barbiturates enhanced the duration of the nerve-terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.
摘要
在含有低浓度钙和高浓度镁的林格氏液中浸泡的青蛙缝匠肌终板上，用电生理学方法研究了巴比妥类药物对神经肌肉传递的影响。
将惊厥性巴比妥类药物5-(2-环己叉乙基)-5-乙基巴比妥酸（CHEB）的作用与苯巴比妥的作用进行了比较。
CHEB和苯巴比妥增加了终板电位的平均量子含量，降低了微小终板电位的平均幅度。
两种巴比妥类药物均延长了神经末梢动作电位的持续时间，对骨骼肌膜的有效电阻几乎没有影响或没有影响。
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本文引用的文献
1
PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS.运动神经末梢电活动的传播
Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:453-82. doi: 10.1098/rspb.1965.0015.
2
Action of tetraethylammonium chloride on neuromuscular transmission in frogs.氯化四乙铵对青蛙神经肌肉传递的作用。
Am J Physiol. 1958 Apr;193(1):213-8. doi: 10.1152/ajplegacy.1958.193.1.213.
3
The distribution and excretion of phenobarbital.苯巴比妥的分布与排泄。
J Clin Invest. 1957 Aug;36(8):1217-26. doi: 10.1172/JCI103518.
4
On the factors which determine the amplitude of the miniature end-plate potential.论决定微小终板电位幅度的因素。
J Physiol. 1957 Jul 11;137(2):267-78. doi: 10.1113/jphysiol.1957.sp005811.
5
The effect of anesthetic agents on skeletal muscle membrane.麻醉剂对骨骼肌膜的作用。
Acta Physiol Scand. 1956 Nov 5;37(4):335-49. doi: 10.1111/j.1748-1716.1956.tb01369.x.
6
A further study of the statistical composition on the end-plate potential.关于终板电位统计构成的进一步研究。
J Physiol. 1955 Oct 28;130(1):114-22. doi: 10.1113/jphysiol.1955.sp005397.
7
Quantal components of the end-plate potential.终板电位的量子成分。
J Physiol. 1954 Jun 28;124(3):560-73. doi: 10.1113/jphysiol.1954.sp005129.
8
Resting potential and electrical properties of frog slow muscle fibres. Effect of different external solutions.青蛙慢肌纤维的静息电位和电特性。不同外部溶液的影响。
J Physiol. 1969 Aug;203(2):383-401. doi: 10.1113/jphysiol.1969.sp008869.
9
The effect of methohexital at the neuromuscular junction.美索比妥在神经肌肉接头处的作用。
Brain Res. 1971 Mar 5;26(2):465-8.
10
Modification of transmitter release by ions which prolong the presynaptic action potential.通过延长突触前动作电位的离子对递质释放的修饰。
J Physiol. 1970 Oct;210(3):681-95. doi: 10.1113/jphysiol.1970.sp009235.
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