慢性淋巴细胞白血病一例中淋巴细胞两个亚群对植物有丝分裂原的反应。

Smith J L, Cawley J C, Barker C R

Clin Exp Immunol. 1973 Jul;14(3):397-408.

The effect of the plant mitogens, phytohaemagglutinin, pokeweed mitogen and concanavalin A, on the peripheral lymphocytes was studied in a case of chronic lymphocytic leukaemia in which the leukaemic cells could be identified by characteristic crystalline IgA inclusions. Compared with normal lymphocytes, the patient's lymphocytes showed reduced and delayed responses during culture for 8 days. Whether assessed by light or electron microscopy or immunofluorescence, cells with inclusions never represented more than a small percentage (approx. 3%) of the transformed cells, or those showing H-thymidine uptake. It was concluded that while a small percentage of the leukaemic cells do transform in response to mitogens, the overall delayed response was due to outgrowth of the normal lymphocyte population.

在一例慢性淋巴细胞白血病患者中，研究了植物有丝分裂原（植物血凝素、商陆有丝分裂原和刀豆球蛋白A）对外周淋巴细胞的影响。在该病例中，白血病细胞可通过特征性的结晶状IgA包涵体来识别。与正常淋巴细胞相比，患者的淋巴细胞在8天培养期内反应降低且延迟。无论通过光学显微镜、电子显微镜还是免疫荧光评估，含有包涵体的细胞在转化细胞或显示H-胸腺嘧啶核苷摄取的细胞中所占比例从未超过一小部分（约3%）。得出的结论是，虽然一小部分白血病细胞确实会对有丝分裂原发生转化，但总体反应延迟是由于正常淋巴细胞群体的生长超过了白血病细胞。