Elston C W, Bagshawe K D
Br J Cancer. 1973 Sep;28(3):245-56. doi: 10.1038/bjc.1973.144.
The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a "severe" cellular reaction than in those with a "mild" reaction to gestational choriocarcinoma. The pathological and clinical features of invasive moles showed no relationship with the cellular reaction to the tumour. The cellular reaction to trophoblastic teratomata was generally poor but there was a marked cellular reaction to the tumour of one patient who has enjoyed a sustained remission.The relationship of cellular reaction and response to treatment with other histological and clinical features was examined. With the exception of a positive correlation between the degree of vascular invasion and response to treatment, none was found.It is suggested that an infiltrate of mononuclear cells in gestational choriocarcinoma is probably a response to the presence of tumour antigens. The infiltrate favourably affects the response to chemotherapeutic agents, suggesting that it contributes to tumour cell death and it may be interpreted as an immunological response directed at tumour rejection.
对41例妊娠性绒毛膜癌、10例侵蚀性葡萄胎和13例恶性滋养层畸胎瘤的单核细胞反应情况进行了研究。对反应强度进行了分级；与妊娠性绒毛膜癌“轻度”反应者相比，“重度”细胞反应者对治疗的反应和生存率明显更好。侵蚀性葡萄胎的病理和临床特征与对肿瘤的细胞反应无关。对滋养层畸胎瘤的细胞反应通常较差，但有一名患者对肿瘤有明显的细胞反应，该患者病情持续缓解。研究了细胞反应以及对治疗的反应与其他组织学和临床特征之间的关系。除了血管侵犯程度与治疗反应呈正相关外，未发现其他相关性。提示妊娠性绒毛膜癌中的单核细胞浸润可能是对肿瘤抗原存在的一种反应。这种浸润对化疗药物的反应有积极影响，表明它有助于肿瘤细胞死亡，并且可以解释为针对肿瘤排斥的免疫反应。
