维拉帕米、丹曲林和镧对大鼠肾上腺髓质儿茶酚胺释放的影响。
Effects of verapamil, dantrolene and lanthanum on catecholamine release from rat adrenal medulla.
作者信息
Cohen J, Gutman Y
出版信息
Br J Pharmacol. 1979 Apr;65(4):641-5. doi: 10.1111/j.1476-5381.1979.tb07876.x.
Abstract
- The release of catecholamines (CA) from rat adrenal incubated in vivo in Locke solution was studied. 2. Acetylcholine-induced release of CA and CA release by 56 mM KCl were inhibited by verapamil and lanthanum chloride which block calcium permeability. 3. CA secretion induced by salbutamol or by theophylline was unaffected by either verapamil or lanthanum chloride. 4. Dantrolene-sodium inhibited the CA secretion induced by theophylline but only partially reduced potassium-induced release of CA. 5. Verapamil enhanced the secretion of CA induced by salbutamol (in a calcium-free medium). 6. Tyramine-induced secretion of CA was unaffected by lanthanum chloride, verapamil or dantrolene-sodium. 7. It is suggested that cyclic adenosine 3',5'-monophosphate-mediated CA secretion (induced by theophylline or salbutamol) depends on release of calcium from intracellular stores, and that CA secretion induced by tyramine is independent of intra- or extracellular calcium.
摘要
- 研究了在洛克溶液中体内孵育的大鼠肾上腺中儿茶酚胺（CA）的释放情况。2. 维拉帕米和氯化镧可抑制乙酰胆碱诱导的CA释放以及56 mM氯化钾引起的CA释放，它们可阻断钙通透性。3. 维拉帕米和氯化镧均不影响沙丁胺醇或茶碱诱导的CA分泌。4. 丹曲林钠可抑制茶碱诱导的CA分泌，但仅部分降低钾诱导的CA释放。5. 维拉帕米增强了（在无钙培养基中）沙丁胺醇诱导的CA分泌。6. 氯化镧、维拉帕米或丹曲林钠均不影响酪胺诱导的CA分泌。7. 提示环磷酸腺苷介导的CA分泌（由茶碱或沙丁胺醇诱导）依赖于细胞内钙库中钙的释放，而酪胺诱导的CA分泌与细胞内或细胞外钙无关。
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