以对鱼精蛋白的低钙血症反应作为骨吸收的一种衡量指标。
The hypocalcemic response to protamine as a measure of bone resorption.
作者信息
Luthman J, Jonson G, Persson J
出版信息
Acta Vet Scand. 1973;14(3):428-35. doi: 10.1186/BF03547430.
The heparin antagonist protamine inhibits bone resorption. In the present study protamine was given i.v. at a dose of 10 mg/kg to goats and sheep in various stages of pregnancy and lactation. It is known that bone resorption increases as pregnancy progresses. In sheep maximum in bone resportion is reached at early lactation. The hypocalcemic response to protamine followed a similar course. The slightest decrease in serum calcium was obtained during early pregnancy and the greatest during late pregnancy and early lactation. Protamine increased serum inorganic phosphorus. The increase was most pronounced during early pregnancy. Protamine did not significantly change serum magnesium. Five lactating ewes were given 25000 i.u./kg of vitamin D3. Serum calcium increased and the hypocalcemic response to protamine was greater after vitamin D administration than before. The results showed that the hypocalcemic response to protamine can be used as an indicator of the role of bone resorption in calcium homeostasis in various physiological situations.
肝素拮抗剂鱼精蛋白可抑制骨吸收。在本研究中，以10mg/kg的剂量对处于妊娠和泌乳不同阶段的山羊和绵羊静脉注射鱼精蛋白。众所周知，随着妊娠进展，骨吸收会增加。在绵羊中，骨吸收在泌乳早期达到最大值。对鱼精蛋白的低钙血症反应也遵循类似的过程。血清钙在妊娠早期下降最轻微，在妊娠后期和泌乳早期下降最大。鱼精蛋白可使血清无机磷升高。这种升高在妊娠早期最为明显。鱼精蛋白对血清镁没有显著影响。给5只泌乳母羊注射25000IU/kg的维生素D3。血清钙升高，维生素D给药后对鱼精蛋白的低钙血症反应比给药前更大。结果表明，对鱼精蛋白的低钙血症反应可作为骨吸收在各种生理情况下钙稳态中作用的指标。
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