一种硫酸化糖肽对组胺、氨甲酰甲胆碱、五肽胃泌素和二丁酰环磷腺苷刺激的大鼠胃酸分泌的影响。
Effect of a sulphated glycopeptide on rat gastric acid secretion stimulated by histamine, bethanechol, pentagastrin and dibutyryl cyclic AMP.
作者信息
Niada R, Prino G
出版信息
Br J Pharmacol. 1973 Jul;48(3):550-2. doi: 10.1111/j.1476-5381.1973.tb08362.x.
Abstract
The antisecretory activity of a semisynthetic sulphated glycopeptide (GLPS) was studied in rats in which the secretion rates of gastric acid were detennined on the perfused stomach preparation. GLPS at 1 mg/kg i.v. reduced the hypersecretory effect of dibutyryl cyclic AMP, histamine, pentagastrin, bethanechol but not of theophylline.
摘要
在通过灌流胃制备法测定胃酸分泌率的大鼠中，研究了一种半合成硫酸化糖肽（GLPS）的抗分泌活性。静脉注射1mg/kg的GLPS可降低二丁酰环磷腺苷、组胺、五肽胃泌素、氨甲酰甲胆碱的分泌过多效应，但对茶碱无效。
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