Church T L, Janzen E D, Sisodia C S, Radostits O M
Can Vet J. 1979 Feb;20(2):41-4.
Studies on the use of sodium sulfamethazine in drinking water at three levels (572, 1028 and 1848 mg/L) were conducted in healthy weaned beef calves under similar dietary and environmental conditions. Blood sulfonamide levels greater than 5 mg/dl were attained with each treatment level but at different time intervals. The maximum levels in blood were achieved with the highest concentration in the water. However, a reduction in water intake caused a lower than anticipated dose of sulfamethazine. Under the conditions of the experiment the administration of sulfonamide in drinking water may be an effective means of mass medication of cattle.
在相似的饮食和环境条件下，对健康的断奶肉牛犊进行了研究，在饮用水中添加三种水平（572、1028和1848毫克/升）的磺胺二甲嘧啶。每种处理水平都能使血液磺胺水平高于5毫克/分升，但达到该水平的时间间隔不同。水中浓度最高时，血液中的磺胺水平达到最高。然而，饮水量的减少导致磺胺二甲嘧啶的摄入量低于预期剂量。在本实验条件下，在饮用水中添加磺胺类药物可能是对牛进行群体用药的一种有效方法。
