Tylén U, Forsberg L, Owman T
Cardiovasc Radiol. 1979 Apr 27;2(2):111-4. doi: 10.1007/BF02575371.
A heparinized catheter was used for the regional infusion of 5-fluorouracil in seven patients with liver metastases. The hepatic artery was catheterized from the left brachial artery. The period of treatment varied from one to 13 weeks. Pull-out angiograms, obtained after eight catheterizations, revealed complete occlusion of the brachial artery in five and partial occlusion in three, although no patient had ischemic symptoms in the hand. Thus, heparinization of the catheter did not prevent thrombosis during long-term infusion therapy.
7例肝转移患者使用肝素化导管进行5-氟尿嘧啶区域灌注。经左肱动脉插入肝动脉导管。治疗时间为1至13周。8次插管后进行的拔管血管造影显示，5例肱动脉完全闭塞，3例部分闭塞，尽管没有患者手部出现缺血症状。因此，导管肝素化并不能防止长期灌注治疗期间的血栓形成。
