Hansen J M, Kampmann J, Madsen S N, Skovsted L, Solgaard S, Grytter C, Grontvedt T, Rasmussen S N
Clin Endocrinol (Oxf). 1979 Jan;10(1):1-6. doi: 10.1111/j.1365-2265.1979.tb03027.x.
The effect of a daily dose of 150 micrograms l-thyroxine for one year was studied in forty-five patients with diffuse non-toxic goitre. Thyroid volume was evaluated by ultrasonic scanning. A decrease in the median value of the thyroid volume of about 20% was found after 3 months of therapy and no further change in the median value was observed in the following 9 months of treatment. About 50% of the patients showed a response to therapy and about 30% obtained normal size of the thyroid gland. Median value of the thyroid volume returned to pretreatment value 3 months after thyroxine therapy was stopped. A considerable increase in serum T4 and free T4 index was noted after 3 months of therapy and these elevated values persisted unaltered during the following 9 months of treatment. Serum T3 was studied before and after 3 months of thyroxine therapy in eleven of the patients. A small and insignificant increase in serum T3 and free T3 index was observed.
对45例弥漫性非毒性甲状腺肿患者研究了每日服用150微克左旋甲状腺素一年的效果。通过超声扫描评估甲状腺体积。治疗3个月后发现甲状腺体积中位数下降约20%，在随后9个月的治疗中未观察到中位数有进一步变化。约50%的患者对治疗有反应，约30%的患者甲状腺恢复正常大小。停止甲状腺素治疗3个月后，甲状腺体积中位数恢复到治疗前水平。治疗3个月后血清T4和游离T4指数显著升高，在随后9个月的治疗中这些升高值持续不变。对11例患者在甲状腺素治疗3个月前后进行了血清T3研究。观察到血清T3和游离T3指数有小幅且无显著意义的升高。
