基因剂量效应：人可溶性谷草转氨酶的带内定位
Gene dosage effect: intraband mapping of human soluble glutamic oxaloacetic transaminase.
作者信息
Spritz R A, Emanuel B S, Chern C J, Mellman W J
出版信息
Cytogenet Cell Genet. 1979;23(3):149-56. doi: 10.1159/000131320.
PMID:436447
Abstract
Quantitative assays of soluble GOT were performed on fibroblasts (from two individuals) with duplications of the long arm of chromosome 10 (10q24 leads to qter). Improved karyologic technique demonstrated that the duplications differ by half a band. Correlation of GOTS activity with the karyologic data indicates that the structural locus for GOTS maps within band 10q24. This study demonstrates the utility of this approach to fine structural mapping of the human genome.
摘要
对具有10号染色体长臂重复（10q24至qter）的成纤维细胞（来自两个人）进行了可溶性谷草转氨酶（GOT）的定量测定。改进的核型分析技术表明，这些重复相差半个条带。GOT活性与核型数据的相关性表明，GOT的结构基因座定位于10q24带内。这项研究证明了这种方法在人类基因组精细结构定位中的实用性。
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Gene dosage effect: intraband mapping of human soluble glutamic oxaloacetic transaminase.基因剂量效应：人可溶性谷草转氨酶的带内定位
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引用本文的文献
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