三态模型：配体与血红蛋白结合中同促效应和异促效应的最小变构描述。
The three-state model: a minimal allosteric description of homotropic and heterotropic effects in the binding of ligands to hemoglobin.
作者信息
Minton A P, Imai K
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1418-21. doi: 10.1073/pnas.71.4.1418.
Abstract
The effect of hydrogen ion, chloride, and 2,3-diphosphoglycerate upon the oxygen binding of hemoglobin may be satisfactorily described by an allosteric model employing three affinity states. The allosteric two-state model does not provide even an approximate description except under defined extreme conditions. In particular, the two-state model cannot provide a correct interpretation of recently reported electron spin resonance and nuclear magnetic resonance data.
摘要
氢离子、氯离子和2,3-二磷酸甘油酸对血红蛋白氧结合的影响，可以用一个采用三种亲和力状态的别构模型令人满意地描述。除了在特定的极端条件下，别构二态模型甚至都不能提供一个近似的描述。特别是，二态模型无法对最近报道的电子自旋共振和核磁共振数据作出正确的解释。
相似文献
1
The three-state model: a minimal allosteric description of homotropic and heterotropic effects in the binding of ligands to hemoglobin.三态模型：配体与血红蛋白结合中同促效应和异促效应的最小变构描述。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1418-21. doi: 10.1073/pnas.71.4.1418.
2
Mechanism of cooperative oxygen binding to hemoglobin: equilibrium aspects.血红蛋白协同氧结合的机制：平衡方面
Biochemistry. 1974 Oct 22;13(22):4579-85. doi: 10.1021/bi00719a017.
3
Allosteric interpretation of haemoglobin properties.血红蛋白特性的变构解释。
Q Rev Biophys. 1975 Jul;8(3):325-420. doi: 10.1017/s0033583500001840.
4
Location of the allosteric site for 2,3-bisphosphoglycerate on human oxy- and deoxyhemoglobin as observed by magnetic resonance spectroscopy.
J Biol Chem. 1979 Sep 10;254(17):8250-5.
5
Interactions between hemoglobin and organic phosphates investigated with 31P nuclear magnetic resonance spectroscopy and ultrafiltration.利用31P核磁共振光谱法和超滤法研究血红蛋白与有机磷酸盐之间的相互作用。
Biochim Biophys Acta. 1976 Apr 14;427(2):481-91. doi: 10.1016/0005-2795(76)90190-2.
6
A model of the pH-dependence of the number of oxygen-linked chloride binding sites in hemoglobin.
Physiol Chem Phys. 1978;10(2):139-43.
7
Manganese hemoglobin: allosteric effects in redox and ligation equilibria.锰血红蛋白：氧化还原和配位平衡中的别构效应
Biochem Biophys Res Commun. 1974 Jul 10;59(1):140-5. doi: 10.1016/s0006-291x(74)80185-3.
8
Molecular conformation and cooperativity in hemoglobin.
Ann N Y Acad Sci. 1973 Dec 31;222:40-55. doi: 10.1111/j.1749-6632.1973.tb15251.x.
9
The interaction of chloride ions with human hemoglobin.
Biochem Biophys Res Commun. 1974 May 7;58(1):210-5. doi: 10.1016/0006-291x(74)90913-9.
10
35Cl NMR study of the release of chloride on oxygen binding to human hemoglobin.
FEBS Lett. 1978 Oct 15;94(2):410-2. doi: 10.1016/0014-5793(78)80988-0.
引用本文的文献
1
Wandering about allostery.变构漫游
Biol Direct. 2024 Aug 8;19(1):64. doi: 10.1186/s13062-024-00502-0.
2
Is allostery a fuzzy concept?变构作用是一个模糊的概念吗？
FEBS Open Bio. 2024 Jul;14(7):1040-1056. doi: 10.1002/2211-5463.13794. Epub 2024 May 23.
3
Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property.调节血红蛋白变构作用治疗镰状细胞病：当前进展和知识产权。
Expert Opin Ther Pat. 2022 Feb;32(2):115-130. doi: 10.1080/13543776.2022.1994945. Epub 2021 Nov 1.
4
Direct observation of conformational population shifts in crystalline human hemoglobin.晶体状人血红蛋白构象群体转移的直接观察
J Biol Chem. 2017 Nov 3;292(44):18258-18269. doi: 10.1074/jbc.M117.781146. Epub 2017 Sep 20.
5
Using the MWC model to describe heterotropic interactions in hemoglobin.使用MWC模型描述血红蛋白中的异促相互作用。
PLoS One. 2017 Aug 9;12(8):e0182871. doi: 10.1371/journal.pone.0182871. eCollection 2017.
6
Experimental basis for a new allosteric model for multisubunit proteins.多亚基蛋白质全新变构模型的实验基础
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12758-63. doi: 10.1073/pnas.1413566111. Epub 2014 Aug 19.
7
Copper active sites in biology.生物学中的铜活性位点。
Chem Rev. 2014 Apr 9;114(7):3659-853. doi: 10.1021/cr400327t. Epub 2014 Mar 3.
8
Protein dynamics explain the allosteric behaviors of hemoglobin.蛋白质动力学解释了血红蛋白的变构行为。
Biochim Biophys Acta. 2008 Sep;1784(9):1146-58. doi: 10.1016/j.bbapap.2008.04.025. Epub 2008 May 8.
9
New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.通过在硅胶中捕获不稳定蛋白质构象对变构机制的新见解。
Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14414-9. doi: 10.1073/pnas.0405987101. Epub 2004 Sep 22.
10
Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation.与O-棉子糖交联可降低氧亲和力，并使血红蛋白稳定在非协同T态构象。
Biochem J. 2004 Dec 1;384(Pt 2):367-75. doi: 10.1042/BJ20040612.
本文引用的文献
1
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.关于别构转变的本质：一个合理的模型。
J Mol Biol. 1965 May;12:88-118. doi: 10.1016/s0022-2836(65)80285-6.
2
Comparison of experimental binding data and theoretical models in proteins containing subunits.含亚基蛋白质中实验结合数据与理论模型的比较。
Biochemistry. 1966 Jan;5(1):365-85. doi: 10.1021/bi00865a047.
3
High resolution nuclear magnetic resonance spectra of hemoglobin. 3. The half-ligated state and allosteric interactions.血红蛋白的高分辨率核磁共振谱。3. 半结合状态与变构相互作用。
J Mol Biol. 1972 Sep 28;70(2):315-36. doi: 10.1016/0022-2836(72)90542-6.
4
An allosteric model of hemoglobin. II. The assumption of independent binding.
Arch Biochem Biophys. 1972 Jul;151(1):68-74. doi: 10.1016/0003-9861(72)90474-2.
5
The action of hemoglobin. Cooperative effects in tetrameric proteins.
Biopolymers. 1972;11(5):957-71. doi: 10.1002/bip.1972.360110504.
6
PH dependence of the shape of the hemoglobin-oxygen equilibrium curve.
Biochim Biophys Acta. 1973 Jun 15;310(2):317-20. doi: 10.1016/0005-2795(73)90111-6.
7
Analysis of oxygen equilibrium of hemoglobin and control mechanism of organic phosphates.血红蛋白的氧平衡分析及有机磷酸盐的调控机制
Biochemistry. 1973 Apr 10;12(8):1491-8. doi: 10.1021/bi00732a004.
8
Thermodynamical analysis of oxygen equilibrium of stripped hemoglobin.
Biochem Biophys Res Commun. 1973 Mar 5;51(1):52-8. doi: 10.1016/0006-291x(73)90506-8.
9
Analyses of oxygen equilibria of native and chemically modified human adult hemoglobins on the basis of Adair's stepwise oxygenation theory and the allosteric model of Monod, Wyman, and Changeux.基于阿代尔逐步氧合理论以及莫诺、怀曼和尚热的别构模型，对天然和化学修饰的成人血红蛋白的氧平衡进行分析。
Biochemistry. 1973 Feb 27;12(5):798-808. doi: 10.1021/bi00729a003.
10
X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin.2,3-二磷酸甘油酸与人类脱氧血红蛋白结合的X射线衍射研究。
Nature. 1972 May 19;237(5351):146-9. doi: 10.1038/237146a0.
Zotero 插件