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变构漫游

Wandering about allostery.

作者信息

Brunori Maurizio

机构信息

Dipartimento di Scienze Biochimiche, Presidente emerito della Classe di Scienze FMN, Accademia Nazionale dei Lincei; Professore emerito di Chimica e Biochimica, Sapienza Università di Roma, Rome, Italy.

出版信息

Biol Direct. 2024 Aug 8;19(1):64. doi: 10.1186/s13062-024-00502-0.

DOI:10.1186/s13062-024-00502-0
PMID:39113091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11308221/
Abstract

It was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept of allosteric control was conceived and gifted to the life science community. In retrospect, this was a demonstration of the skill and imagination of a few intelligent scientists that I happened to be close to. Those talents demonstrated the power of creativity as pictured by the motto "Mens agitat molem"; a celebration of humanism and intellect that paved the way to novel discoveries in the field of structure function relationships in proteins. I have presented hereby some of the events and the people as emerged from my memory over three decades of exciting scientific life.

摘要

1961年杰弗里斯·怀曼抵达罗马时,能与埃拉尔多·安东尼尼一起研究血红蛋白和肌红蛋白,真是太幸运了。当别构控制的概念诞生并被赋予生命科学界时,我发现自己与许多富有创造力的科学家有了联系。回想起来,这展示了一些我恰好与之亲近的聪明科学家的技巧和想象力。这些才华展示了“精神驱动物质”这句座右铭所描绘的创造力的力量;这是对人文主义和智慧的颂扬,为蛋白质结构功能关系领域的新发现铺平了道路。在此,我讲述了三十多年令人兴奋的科学研究生涯中我记忆中的一些事件和人物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/9aa6f2a2252c/13062_2024_502_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/8fe764a43a49/13062_2024_502_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/e2752da90961/13062_2024_502_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/e38d6a5aa71d/13062_2024_502_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/576dba249f55/13062_2024_502_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/54a6b6b7257f/13062_2024_502_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/5a831c8bb2e6/13062_2024_502_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/9aa6f2a2252c/13062_2024_502_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/8fe764a43a49/13062_2024_502_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/e2752da90961/13062_2024_502_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/e38d6a5aa71d/13062_2024_502_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/576dba249f55/13062_2024_502_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/54a6b6b7257f/13062_2024_502_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/5a831c8bb2e6/13062_2024_502_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d3/11308221/9aa6f2a2252c/13062_2024_502_Fig7_HTML.jpg

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本文引用的文献

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Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.对单晶和硅胶中血红蛋白的实验区分了变构模型。
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