Bönner G, Helber A, Meurer K A, Hummerich W, Wambach G, Kaufmann W
Dtsch Med Wochenschr. 1979 Mar 23;104(12):432-7. doi: 10.1055/s-0028-1103925.
The saralasin test was performed in 68 hypertensives. A clear-cut dependence of the test results on initial plasma-renin concentration and particular sodium balance was demonstrated. Because of this dependence the saralasin test should be performed only under constant conditions. A mild stimulation of the renin-angiotension system by salt restriction to a mean sodium excretion of 50 mmol daily and 80 mg furosemide by mouth 12 hours before the test seems best. In this way essential and renovascular hypertension could be distinguished with considerable reliability (P less than 0.001). Among patients with essential hypertension one could clearly separate those with high plasma-renin concentration from those with a normal or low one. Among patients with renovascular hypertension those with haemodynamically significant renal artery stenosis could with high probability be distinguished from those with non-effective stenosis. A positive saralasin test without testing the function of the normal contralateral kidney does not provide an indication for operation.
对68例高血压患者进行了沙拉新试验。结果表明，试验结果与初始血浆肾素浓度及特定钠平衡存在明确的相关性。由于这种相关性，沙拉新试验应仅在恒定条件下进行。试验前12小时通过限制盐摄入使每日平均钠排泄量达到50 mmol，并口服80 mg速尿，以此对肾素 - 血管紧张素系统进行轻度刺激似乎是最佳方法。通过这种方式，可以相当可靠地鉴别原发性高血压和肾血管性高血压（P小于0.001）。在原发性高血压患者中，可以明确区分血浆肾素浓度高的患者和正常或低血浆肾素浓度的患者。在肾血管性高血压患者中，血流动力学上有显著意义的肾动脉狭窄患者很有可能与无功能性狭窄的患者区分开来。未检测对侧正常肾脏功能而沙拉新试验呈阳性，并不能作为手术指征。
