细胞色素c的一种假定的氢转移功能。
A proposed hydrogen transfer function for cytochrome c.
作者信息
Harrison J E
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2332-4. doi: 10.1073/pnas.71.6.2332.
Abstract
Outlines of proposed mechanisms for cytochrome c oxidoreduction are presented which differ in detail from those previously published. The mechanisms, while accommodating the fact that cytochrome c is a net electron acceptor and donor in its catalytic cycle, dictate that the enzyme catalyses hydrogen transfer. It is shown that the mechanism of cytochrome c reduction fulfills a recent proposal that the transition state is an analogue of the structure of ferricytochrome c(2). The implications of a hydrogen transfer role of cytochrome c are discussed.
摘要
本文提出了细胞色素c氧化还原的机制概述，这些机制在细节上与先前发表的有所不同。这些机制虽然考虑到细胞色素c在其催化循环中是净电子受体和供体这一事实，但表明该酶催化氢转移。结果表明，细胞色素c还原机制符合最近的一项提议，即过渡态是高铁细胞色素c(2)结构的类似物。文中讨论了细胞色素c氢转移作用的意义。
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本文引用的文献
1
Enzymic redox reactions of cytochromes c.细胞色素c的酶促氧化还原反应
Biochem Biophys Res Commun. 1972 Dec 4;49(5):1329-35. doi: 10.1016/0006-291x(72)90612-2.
2
The structure of ferrocytochrome c at 2.45 A resolution.分辨率为2.45埃的亚铁细胞色素c的结构。
J Biol Chem. 1973 Aug 10;248(15):5234-55.
3
Structural bases for function in cytochromes c. An interpretation of comparative x-ray and biochemical data.
J Biol Chem. 1973 Nov 25;248(22):7701-16.
4
Water and cytochrome oxidation-reduction reactions.水与细胞色素氧化还原反应。
Biochim Biophys Acta. 1973 Feb 22;292(2):297-309. doi: 10.1016/0005-2728(73)90037-6.
5
Kinetics of electron transfer between cardiac cytochrome c 1 and c.
J Biol Chem. 1973 Jan 25;248(2):528-33.
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