关于一种小鼠自发性下运动神经元变性形式——摇摆（wa）小鼠的研究。
Studies on a murine form of spontaneous lower motor neuron degeneration--the wobbler (wa) mouse.
作者信息
Andrews J M, Gardner M B, Wolfgram F J, Ellison G W, Porter D D, Brandkamp W W
出版信息
Am J Pathol. 1974 Jul;76(1):63-78.
Abstract
The wobbler (wr) mouse has been considered an animal model of spontaneous lower motor neuron degeneration which is inherited as an autosomal recessive trait. Previously available data are, however, also compatible with genetic factors playing a necessary though not exclusive role in the expression of the wobbler trait. The present report describes the results of chromosome analyses, electromyography and selected histochemical studies on wobbler mice, as well as studies exploring the possible participation of infectious agents, transneuronal effects, retrograde effects, aging, circulating toxins and immunologic factors in the pathogenesis of the wobbler disorder. The data obtained do not implicate any of these mechanisms in the pathogenesis of the wobbler trait and also indicate that the wobbler mouse is not a clinical variant of the recently described type C oncornavirus-induced murine paralytic disease.
摘要
摇尾小鼠（wr）被认为是一种自发性下运动神经元变性的动物模型，其遗传方式为常染色体隐性遗传。然而，先前已有的数据也表明，遗传因素在摇尾性状的表达中起到了必要但非唯一的作用。本报告描述了对摇尾小鼠进行染色体分析、肌电图检查和选定的组织化学研究的结果，以及探讨感染因子、跨神经元效应、逆行效应、衰老、循环毒素和免疫因素在摇尾症发病机制中可能参与情况的研究。所获得的数据并未表明这些机制中的任何一种与摇尾性状的发病机制有关，同时也表明摇尾小鼠并非最近描述的C型致癌RNA病毒诱导的小鼠麻痹性疾病的临床变体。
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