Birkmayer W
Aktuelle Gerontol. 1979 Oct;9(10):465-7.
Biological functions are regulated by feedback mechanisms. In old age disorders occur in this regulation by insufficiency of biochemical transmitters. The synthesizing enzymes of Tyrosine Hydroxylase, Tryptophan Hydroxylase, Dopa Decarboxylase and 5-Hydroxytryptophan Decarboxylase are diminished in old age. Minus symptoms as depression, or exhaustion and disorders of circulation occur. A substitution by biogenic transmitters is not possible, because these don't pass the blood-brain-barriere. Therefore a medication of psychopharmacological drugs is necessary. For instance Anxiety--tranquilizer, exhaustion--anti depressive drugs.
生物功能受反馈机制调节。在老年时,由于生化递质不足,这种调节会出现紊乱。酪氨酸羟化酶、色氨酸羟化酶、多巴脱羧酶和5-羟色氨酸脱羧酶的合成酶在老年时会减少。出现如抑郁、疲惫和循环系统紊乱等负面症状。用生物递质替代是不可能的,因为这些递质无法通过血脑屏障。因此,使用精神药理药物进行治疗是必要的。例如,焦虑——使用镇静剂,疲惫——使用抗抑郁药物。