氮杂环丙烷作为黄素单加氧酶中可能的中间体。
Oxaziridines as possible intermediates in flavin monooxygenases.
作者信息
Orf H W, Dolphin D
出版信息
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2646-50. doi: 10.1073/pnas.71.7.2646.
Abstract
The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed "carbonyl oxide" and flavin peroxide models are discussed.
摘要
黄素单加氧酶的酶促羟基化反应被认为涉及氮丙啶作为活性氧化试剂。这些单加氧酶及其非酶模型系统的化学性质与氮丙啶中间体一致。讨论了氮丙啶模型相对于先前提出的“羰基氧化物”和黄素过氧化物模型的几个优点。
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