与抗利尿激素作用机制相关的靶细胞极性和膜磷酸化
Target cell polarity and membrane phosphorylation in relation to the mechanism of action of antidiuretic hormone.
作者信息
Schwartz I L, Shlatz L J, Kinne-Saffran E, Kinne R
出版信息
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2595-9. doi: 10.1073/pnas.71.7.2595.
Abstract
The plasma membrane of the bovine renal collecting duct epithelial cell has been resolved into its apical (luminal) and basal-lateral (contraluminal) components by free flow electrophoresis. The contraluminal, but not the luminal, membrane was found to contain antidiuretic hormone-sensitive adenylate cyclase. The luminal membrane was found to contain a cyclic 3':5'-adenosine monophosphate-sensitive self-phosphorylating system consisting of a membrane-bound protein kinase and its membrane-bound substrate(s); this intrinsic protein kinase was not present in the contraluminal membrane. These findings provide direct evidence that the initiating steps in the action of antidiuretic hormone on the kidney take place at the contraluminal pole of the hormonesensitive target cell and that the late or terminal steps occur at the luminal pole, where they involve an alteration in the level of membrane phosphorylation.
摘要
通过自由流动电泳，牛肾集合管上皮细胞的质膜已被分离为其顶端（管腔）和基底外侧（对管腔）成分。发现对管腔侧而非管腔侧的膜含有抗利尿激素敏感的腺苷酸环化酶。发现管腔侧膜含有一个由膜结合蛋白激酶及其膜结合底物组成的环3':5'-腺苷单磷酸敏感的自磷酸化系统；这种内在蛋白激酶不存在于对管腔侧膜中。这些发现提供了直接证据，表明抗利尿激素对肾脏作用的起始步骤发生在激素敏感靶细胞的对管腔极，而后期或终末步骤发生在管腔极，在那里它们涉及膜磷酸化水平的改变。
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Target cell polarity and membrane phosphorylation in relation to the mechanism of action of antidiuretic hormone.与抗利尿激素作用机制相关的靶细胞极性和膜磷酸化
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2595-9. doi: 10.1073/pnas.71.7.2595.
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
QUANTITATIVE MICRODETERMINATION OF ENZYMES IN SWEAT GLAND. 3. SUCCINIC DEHYDROGENASE IN CYSTIC FIBROSIS.汗腺中酶的定量微量测定。3. 囊性纤维化中的琥珀酸脱氢酶。
Proc Soc Exp Biol Med. 1965 Jun;119:470-3. doi: 10.3181/00379727-119-30213.
3
Structure of the toad's urinary bladder as related to its physiology.蟾蜍膀胱的结构与其生理学的关系。
J Biophys Biochem Cytol. 1961 Aug;10(4):529-53. doi: 10.1083/jcb.10.4.529.
4
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
5
[Renal tubular hydrogen-ion secretion in mammals].[哺乳动物肾小管氢离子分泌]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1958;267(5):491-6. doi: 10.1007/BF00361735.
6
Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules.血管加压素和环磷酸腺苷对离体集合管通透性的影响。
Am J Physiol. 1966 Jul;211(1):255-9. doi: 10.1152/ajplegacy.1966.211.1.255.
7
The role of adenosine 3',5'-phosphate in the action of antidiuretic hormone.3',5'-磷酸腺苷在抗利尿激素作用中的角色。
Am J Med. 1967 May;42(5):757-68. doi: 10.1016/0002-9343(67)90093-9.
8
Membrane effects of antidiuretic hormone.抗利尿激素的膜效应
Am J Med. 1967 May;42(5):745-56. doi: 10.1016/0002-9343(67)90092-7.
9
The physiology of the urinary bladder of amphibia.
Biol Rev Camb Philos Soc. 1966 May;41(2):275-316. doi: 10.1111/j.1469-185x.1966.tb01494.x.
10
[8-Arginine]-vasopressinoic acid: an inhibitor of rabbit kidney adenyl cyclase.
Science. 1970 Feb 20;167(3921):1134-5. doi: 10.1126/science.167.3921.1134.
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