Inhibitory effect of tripeptides containing L-Phe-L-Tyr on neuronal excitability.
作者信息
Takeuchi H, Tamura H, Nishizawa R
出版信息
Eur J Pharmacol. 1979 Mar 15;54(4):393-6. doi: 10.1016/0014-2999(79)90070-0.
PMID:436939
Abstract
Eight tripeptides containing L-Phe-L-Tyr were synthesized, and their effects on the excitability of a giant neurone (tonically autoactive neurone, TAN), identified in the suboesophageal ganglion of an African giant snail (Achiatina fulica Férussac), were examined. Of these tripeptides, the following three showed a marked inhibitory effect: L-Glu-L-Phe-L-Tyr (most effective; critical concentration: 3 X 10(-6)--10(-5) M), Gly-L-Phe-L-Tyr and sarcosine-L-Phe-L-Tyr. The TAN inhibition caused by L-Glu-L-Phe-L-Tyr was not due to an increased membrane permeability to chloride ions.
摘要
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