芳香族氨基酸衍生物对非洲大蜗牛（Achatina fulica Férussac）一种可识别的巨型神经元兴奋性的影响。
The effects of aromatic amino acid derivatives on the excitability of an identifiable giant neurone of the African giant snail (Achatina fulica Férussac).
作者信息
Takeuchi H, Tamura H
出版信息
Br J Pharmacol. 1980 May;69(1):29-34. doi: 10.1111/j.1476-5381.1980.tb10879.x.
Abstract
1 The effects of derivatives of aromatic amino acids on the excitability of an identifiable giant neurone (TAN, tonically autoactive neurone) of the African giant snail (Achatina fulica Férussac) were examined. 2 The following substances had marked inhibitory effects on TAN using bath application: N-beta-phenylpropionyl-L-Tyr and N-beta-phenylpropionyl-L-Trp (critical concentration, 3 x 10(-7) M), N-beta-phenylpropionyl-L-Phe, N-cinnamoyl-DL-Trp and N-phenoxyacetyl-L-Trp (critical concentration, 10(-5) to 3 x 10(-5) M). However, N-beta-phenylpropionyl-D-Tyr and N-beta-phenylpropionyl tyramine had no effect. 3 Microdrop (150 micrometers in diameter) application of N-beta-phenylpropionyl-L-Tyr or N-beta-phenylpropionyl-l-trp containing about 100 pg resulted in marked inhibitory effects on TAN. The effect was observed in Ca2+-free, Mg2+-rich (24 mM) solution. Substitution of Cl- by acetate did not alter the response. This indicates that the two substances act directly on the TAN membrane and not via synaptic influences, and that the inhibition produced by the two substances is not due to the permeability increase of the TAN membrane to Cl-.
摘要
- 研究了芳香族氨基酸衍生物对非洲大蜗牛（Achatina fulica Férussac）一种可识别的巨型神经元（TAN，紧张性自发放电神经元）兴奋性的影响。2. 通过浴槽给药，以下物质对TAN有显著抑制作用：N-β-苯丙酰基-L-酪氨酸和N-β-苯丙酰基-L-色氨酸（临界浓度，3×10⁻⁷ M）、N-β-苯丙酰基-L-苯丙氨酸、N-肉桂酰-DL-色氨酸和N-苯氧乙酰基-L-色氨酸（临界浓度，10⁻⁵至3×10⁻⁵ M）。然而，N-β-苯丙酰基-D-酪氨酸和N-β-苯丙酰基酪胺没有作用。3. 微滴（直径150微米）施加含约100皮克的N-β-苯丙酰基-L-酪氨酸或N-β-苯丙酰基-L-色氨酸对TAN有显著抑制作用。在无钙、富含镁（24 mM）的溶液中观察到该效应。用醋酸盐替代氯离子不会改变反应。这表明这两种物质直接作用于TAN膜，而非通过突触影响，并且这两种物质产生的抑制作用不是由于TAN膜对氯离子的通透性增加。
相似文献
1
The effects of aromatic amino acid derivatives on the excitability of an identifiable giant neurone of the African giant snail (Achatina fulica Férussac).芳香族氨基酸衍生物对非洲大蜗牛（Achatina fulica Férussac）一种可识别的巨型神经元兴奋性的影响。
Br J Pharmacol. 1980 May;69(1):29-34. doi: 10.1111/j.1476-5381.1980.tb10879.x.
2
Inhibitory effects of aromatic oligopeptides on the excitability of identifiable giant neurones of an African giant snail (Achatina fulica Férussac).
Arch Int Pharmacodyn Ther. 1979 Jan;237(1):149-68.
3
Effects of N-beta-phenylpropionyl-L-tyrosine and its derivatives on the excitability of an identifiable giant neuron of Achatina fulica férussac.
Comp Biochem Physiol C Comp Pharmacol. 1982;72(2):225-9. doi: 10.1016/0306-4492(82)90087-9.
4
Structure-activity relationships of N-beta-phenylpropionyl-L-tyrosine and its derivatives on the inhibition of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac).N-β-苯丙酰基-L-酪氨酸及其衍生物对非洲大蜗牛（Achatina fulica Férussac）一种可识别的巨型神经元抑制作用的构效关系
Br J Pharmacol. 1982 Dec;77(4):631-9. doi: 10.1111/j.1476-5381.1982.tb09341.x.
5
[Effect of oligopeptides containing L-Phe, L-Tyr, L-Trp, L-His or L-Met on the excitability of the 2 giant neurons of the African giant snail (Achatina fulica Ferussac)].
C R Seances Soc Biol Fil. 1979;173(5):989-99.
6
Effects of some oligopeptides, consisting of aromatic amino acids, on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac).
Experientia. 1977 Oct 15;33(10):1348-50. doi: 10.1007/BF01920174.
7
Inhibitory effects of ergot alkaloids and their derivatives on the excitability of an identifiable giant neurone of the African giant snail (Achatina fulica Férussac).
Arch Int Pharmacodyn Ther. 1980 May;245(1):56-73.
8
[Effects of clavines, ergot alkaloids, on the membrane potential of an identifiable giant neuron of the African giant snail Achatina fulica Ferussac].
C R Seances Soc Biol Fil. 1980;174(3):290-6.
9
[Inhibitory effects of dipeptides containing tryptophan on the excitability on the giant neuron of the giant African snail (Achatina fulica, Ferussac)].
C R Seances Soc Biol Fil. 1978;172(3):588-95.
10
Inhibitory effect of tripeptides containing L-Phe-L-Tyr on neuronal excitability.
Eur J Pharmacol. 1979 Mar 15;54(4):393-6. doi: 10.1016/0014-2999(79)90070-0.
引用本文的文献
1
Structure-activity relationships of N-beta-phenylpropionyl-L-tyrosine and its derivatives on the inhibition of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac).N-β-苯丙酰基-L-酪氨酸及其衍生物对非洲大蜗牛（Achatina fulica Férussac）一种可识别的巨型神经元抑制作用的构效关系
Br J Pharmacol. 1982 Dec;77(4):631-9. doi: 10.1111/j.1476-5381.1982.tb09341.x.
本文引用的文献
1
ISOLATION AND AMINO ACID SEQUENCE OF PHYSALAEMIN, THE MAIN ACTIVE POLYPEPTIDE OF THE SKIN OF PHYSALAEMUS FUSCUMACULATUS.深色斑泡蟾皮肤主要活性多肽——泡蟾肽的分离及氨基酸序列分析
Arch Biochem Biophys. 1964 Nov;108:341-8. doi: 10.1016/0003-9861(64)90395-9.
2
Nucleolar localization of succinic dehydrogenase in human malignant cells with MTT.用MTT法检测琥珀酸脱氢酶在人恶性细胞中的核仁定位
Experientia. 1962 Dec 15;18:562. doi: 10.1007/BF02172179.
3
Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus.深色斑蟾皮肤主要活性多肽——雨蛙肽的结构与药理作用
Experientia. 1964 Sep 15;20(9):489-90. doi: 10.1007/BF02154064.
4
[Concentration of inorganic ions in the hemolymph of the giant African snail (Achatina fulica Ferussac) as a function of its nutritional state].
C R Seances Soc Biol Fil. 1973;167(3):598-602.
5
Effects of glutamic acid relatives on the electrical activity of an identified molluscan giant neurone (Achatina fulica Férussac).
Brain Res. 1976 Feb 20;103(2):261-74. doi: 10.1016/0006-8993(76)90798-8.
6
Effects of biologically active peptides on the excitability of identifiable giant neurones of an African giant snail (Achatina fulica férussac).生物活性肽对非洲大蜗牛（非洲大蜗牛费鲁萨克亚种）可识别的巨型神经元兴奋性的影响。
Neuropharmacology. 1977 Sep;16(9):593-602. doi: 10.1016/0028-3908(77)90029-6.
7
Effects of some oligopeptides, consisting of aromatic amino acids, on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac).
Experientia. 1977 Oct 15;33(10):1348-50. doi: 10.1007/BF01920174.
8
Inhibitory tripeptide, Lys-Phe-Tyr, as a fragment of physalaemin.
Experientia. 1977 Jul 15;33(7):938-9. doi: 10.1007/BF01951293.
9
Modification of effects of biologically active peptides, caused by enzyme treatment, on the excitability of identifiable giant neurones of an African giant snail (Achatina fulica Férussac).
Experientia. 1977 Feb 15;33(2):249-51. doi: 10.1007/BF02124093.
10
Inhibitory effects of aromatic oligopeptides on the excitability of identifiable giant neurones of an African giant snail (Achatina fulica Férussac).
Arch Int Pharmacodyn Ther. 1979 Jan;237(1):149-68.
Zotero 插件