环磷酸鸟苷：C3H小鼠视网膜变性光感受器细胞中的升高。
Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.
作者信息
Farber D B, Lolley R N
出版信息
Science. 1974 Nov 1;186(4162):449-51. doi: 10.1126/science.186.4162.449.
PMID:4369896
Abstract
As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.
摘要
由于早期环核苷酸磷酸二酯酶活性缺乏，3',5'-环磷酸鸟苷在视网膜光感受器细胞开始退化之前就在其中积累。有人提出，光感受器细胞的退化与环磷酸鸟苷水平升高所导致的代谢或功能失衡有关。
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