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环磷酸鸟苷：C3H小鼠视网膜变性光感受器细胞中的升高。

Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.

作者信息

Farber D B, Lolley R N

出版信息

Science. 1974 Nov 1;186(4162):449-51. doi: 10.1126/science.186.4162.449.

DOI:10.1126/science.186.4162.449
PMID:4369896
Abstract

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.

摘要

由于早期环核苷酸磷酸二酯酶活性缺乏，3',5'-环磷酸鸟苷在视网膜光感受器细胞开始退化之前就在其中积累。有人提出，光感受器细胞的退化与环磷酸鸟苷水平升高所导致的代谢或功能失衡有关。

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Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.环磷酸鸟苷：C3H小鼠视网膜变性光感受器细胞中的升高。
Science. 1974 Nov 1;186(4162):449-51. doi: 10.1126/science.186.4162.449.
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Alterations in cyclic AMP metabolism associated with photoreceptor cell degeneration in the C3H mouse.与C3H小鼠光感受器细胞变性相关的环磷酸腺苷代谢改变。
J Neurochem. 1974 May;22(5):701-7. doi: 10.1111/j.1471-4159.1974.tb04283.x.
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Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina.小鼠视网膜退行性变光感受器细胞中环鸟苷酸积累的酶学基础。
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Abnormal guanosine 3', 5'-monophosphate during photoreceptor degeneration in the inherited retinal disorder of C3H/HeJ mice.遗传性视网膜疾病C3H/HeJ小鼠光感受器变性过程中异常的3',5'-环磷酸鸟苷。
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Cyclic nucleotide metabolism in the retina.视网膜中的环核苷酸代谢
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Cyclic-nucleotide phosphodiesterase: an early defect in inherited retinal degeneration of C3H mice.环核苷酸磷酸二酯酶：C3H小鼠遗传性视网膜变性的早期缺陷
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Effects of light on cyclic GMP metabolism in retinal photoreceptors.光对视网膜光感受器中环磷酸鸟苷代谢的影响。
J Neurochem. 1976 Sep;27(3):717-22. doi: 10.1111/j.1471-4159.1976.tb10399.x.
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Letter: Phosphodiesterase: an important role in cyclic nucleotide regulation in the retina.信函：磷酸二酯酶：在视网膜环核苷酸调节中起重要作用。
Exp Eye Res. 1973 Dec 10;17(5):483-6. doi: 10.1016/0014-4835(73)90229-7.
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Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells.爱尔兰赛特犬的视杆-视锥细胞发育异常：视觉细胞中环鸟苷酸代谢的缺陷。
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The role of cyclic nucleotides in visual excitation.环核苷酸在视觉兴奋中的作用。
Life Sci. 1973 Dec 1;13(11):1451-72. doi: 10.1016/0024-3205(73)90133-1.

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