Kudriashov B A, Kolomina S M, Kalishevskaia T M, Pogodina L S, Chentsov Iu S
Farmakol Toksikol. 1979 Mar-Apr;42(2):147-55.
Sarcoma 45 cells were inoculated subcutaneously to rats and carcinosarcoma. Walker 256 cells implanted intramuscularly in the Wistar rats. The injections of the heparin-urea complex with a simultaneous blocking of the vegetative nerves system created an anticoagulant and fibrinolytic background in the organism of these animals and produced an antitumorigenic effect, i.e. the inhibition of growth of primary tumors and metastases, the mitotic activity decline in the malignant tissue and a change in the submicroscopic structure of the sarcoma 45 cells (greater chromatin density, prevalence of the fibrillar component in the nuclei, swelling of the reticulum channels, condensation of mitochondria and reduction of polysomes). All this shows the physiological activity of malignant cells to decline through imitating the hyperfunction of the anticoagulation blood system.
将肉瘤45细胞皮下接种到大鼠和癌肉瘤中。将沃克256细胞肌肉注射到Wistar大鼠体内。注射肝素-尿素复合物并同时阻断植物神经系统，在这些动物体内营造了抗凝和纤溶背景，并产生了抗肿瘤作用，即抑制原发性肿瘤和转移瘤的生长、恶性组织有丝分裂活性下降以及肉瘤45细胞亚微观结构发生变化（染色质密度增加、细胞核中纤维状成分占优势、网状通道肿胀、线粒体凝聚和多核糖体减少）。所有这些表明恶性细胞的生理活性通过模拟抗凝血液系统的功能亢进而下降。
