Kolomina S M, Chentsov Iu S, Kalishevskaia T M, Kudriashov B A, Murasheva M I
Eksp Onkol. 1985;7(1):60-4.
It is shown that the damage of sarcoma 45 cells at different stages of cell life cycle occurs under the effect of vinblastine treatment against a background of higher activity of the blood anticoagulating system. A decrease in the mitotic activity, mitosis accumulation in prophase and especially in the metaphase as well as essential changes in the interphase cell ultrastructure are detected.
结果表明，在血液抗凝系统活性较高的背景下，长春碱处理会导致肉瘤45细胞在细胞生命周期不同阶段受到损伤。检测到有丝分裂活性降低、前期尤其是中期有丝分裂积累以及间期细胞超微结构发生显著变化。
