新型钙离子拮抗剂盐酸8-(N,N-二乙氨基)辛基3,4,5-三甲氧基苯甲酸酯（TMB-8）的药理学评价：骨骼肌研究 - Suppr

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Pharmacological evaluation of a new Ca++ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles.

作者信息

Malagodi M H, Chiou C Y

出版信息

Pharmacology. 1974;12(1):20-31. doi: 10.1159/000136517.

DOI:10.1159/000136517

PMID:4371232

Abstract

摘要

相似文献

Pharmacological evaluation of a new Ca++ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles.新型钙离子拮抗剂盐酸8-(N,N-二乙氨基)辛基3,4,5-三甲氧基苯甲酸酯（TMB-8）的药理学评价：骨骼肌研究

Pharmacology. 1974;12(1):20-31. doi: 10.1159/000136517.

Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles.新型钙离子拮抗剂盐酸8-（N，N-二乙氨基）辛基-3,4,5-三甲氧基苯甲酸酯（TMB-8）的药理学评价：平滑肌研究

Eur J Pharmacol. 1974 Jun;27(1):25-33. doi: 10.1016/0014-2999(74)90198-8.

Effects of TMB-8, a putative calcium antagonist, on neuromuscular transmission and muscle contractility in the mouse phrenic nerve-hemidiaphragm preparation.一种假定的钙拮抗剂TMB-8对小鼠膈神经-半膈肌标本中神经肌肉传递及肌肉收缩性的影响。

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Studies on the neuropharmacology of papaverine. I. The curare-like action isolated nerve-muscle preparation.罂粟碱的神经药理学研究。I. 箭毒样作用（离体神经-肌肉标本）

Neuropharmacology. 1971 Jul;10(4):499-506. doi: 10.1016/0028-3908(71)90077-3.

Studies on the mechanism of action of a new Ca-2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles.新型钙拮抗剂盐酸8-(N,N-二乙氨基)辛基3,4,5-三甲氧基苯甲酸酯在平滑肌和骨骼肌中的作用机制研究

Br J Pharmacol. 1975 Feb;53(2):279-85. doi: 10.1111/j.1476-5381.1975.tb07359.x.

Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant.丹曲林钠作用机制的研究。一种骨骼肌松弛剂。

Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):83-94. doi: 10.1007/BF00505069.

The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle.箭毒蛙毒素的药理学。I. 对哺乳动物骨骼肌收缩机制和神经肌肉传递的影响。

J Pharmacol Exp Ther. 1971 Mar;176(3):497-510.

Effects of 8-(N-N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) on skinned myocardial fibres of the rat: reversible inhibition of calcium release from the sarcoplasmic reticulum.盐酸8-（N-N-二乙氨基）辛基-3,4,5-三甲氧基苯甲酸酯（TMB-8）对大鼠去表皮心肌纤维的影响：对肌浆网钙释放的可逆性抑制

Naunyn Schmiedebergs Arch Pharmacol. 1996 Nov;354(5):650-5. doi: 10.1007/BF00170841.

TMB-8 can block twitches without blocking high K+ or caffeine induced contractures in frog's skeletal muscle.8-四甲基联苯二胺（TMB-8）可阻断青蛙骨骼肌的抽搐，但不阻断高钾或咖啡因诱导的挛缩。

Life Sci. 1986 Sep 29;39(13):1137-41. doi: 10.1016/0024-3205(86)90344-9.

Relaxing effect of spermine and spermidine on intact and glycerol-treated muscle.精胺和亚精胺对完整及甘油处理肌肉的松弛作用。

Am J Physiol. 1967 Jan;212(1):92-6. doi: 10.1152/ajplegacy.1967.212.1.92.

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Naunyn Schmiedebergs Arch Pharmacol. 1996 Nov;354(5):650-5. doi: 10.1007/BF00170841.

8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) acts as a muscarinic receptor antagonist in the epithelial cell line HT29.8-（N，N-二乙氨基）辛基3,4,5-三甲氧基苯甲酸酯（TMB-8）在HT29上皮细胞系中作为一种毒蕈碱受体拮抗剂发挥作用。

Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):295-301. doi: 10.1007/BF00168631.

A comparison of the effects of TMB-8 and nifedipine on pressor responses to alpha 1- and alpha 2-adrenoceptor agonists in pithed rats.TMB - 8与硝苯地平对去脑大鼠对α1和α2肾上腺素能受体激动剂升压反应影响的比较。

Naunyn Schmiedebergs Arch Pharmacol. 1995 May;351(5):500-6. doi: 10.1007/BF00171041.

Properties of concanavalin A-elicited granule exocytosis from human polymorphonuclear neutrophils.伴刀豆球蛋白A诱导人多形核中性粒细胞颗粒胞吐作用的特性

Inflammation. 1980 Dec;4(4):343-58. doi: 10.1007/BF00916046.

Characteristics of N-formyl-methionyl-leucyl-phenylalanine as an inducer of lysosomal enzyme release from human neutrophils.N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸作为人中性粒细胞溶酶体酶释放诱导剂的特性

Inflammation. 1980 Mar;4(1):73-88. doi: 10.1007/BF00914105.

Extra- and intracellular Ca2+ requirements for lysosomal enzyme secretion in human neutrophils.人类中性粒细胞溶酶体酶分泌所需的细胞外和细胞内钙离子

Agents Actions. 1982 Jul;12(3):328-32. doi: 10.1007/BF01965398.

The intracellular calcium antagonist TMB-8 [8-(NN-diethylamino)octyl-3,4,5-trimethoxybenzoate] inhibits mitochondrial ATP production in rat thymocytes.细胞内钙拮抗剂TMB - 8 [8 -（NN -二乙氨基）辛基- 3,4,5 -三甲氧基苯甲酸酯]抑制大鼠胸腺细胞中的线粒体ATP生成。

Biochem J. 1984 Dec 15;224(3):1027-30. doi: 10.1042/bj2241027.

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