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天花疫苗的人类致病性与高温下病毒生长之间的可能关系。

A possible relation between human pathogenicity of smallpox vaccines and virus growth at elevated temperatures.

作者信息

Baxby D

出版信息

J Hyg (Lond). 1974 Aug;73(1):35-7. doi: 10.1017/s0022172400023809.

Abstract

Seven smallpox vaccines of known human pathogenicity were tested for their ability to produce pocks on the chick chorioallantois at 39.7 degrees C. Significant differences were found and the more pathogenic strains produced pocks with greater efficiency at 39.7 degrees C. than did strains of average or low pathogenicity.

摘要

对七种已知具有人类致病性的天花疫苗进行了测试,以检测它们在39.7摄氏度下于鸡胚绒毛尿囊膜上产生痘疱的能力。结果发现存在显著差异,致病性更强的毒株在39.7摄氏度下产生痘疱的效率高于平均致病性或低致病性的毒株。

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Lancet. 1963 Nov 23;2(7317):1085-8. doi: 10.1016/s0140-6736(63)92857-5.
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J Gen Virol. 1967 Jul;1(3):399-402. doi: 10.1099/0022-1317-1-3-399.

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