三种类型平滑肌中血管紧张素II及合成类似物的剂量反应曲线：血管紧张素II不同形式受体位点的存在
Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle: existence of different forms of receptor sites for angiotensin II.
作者信息
Papadimitriou A, Worcel M
出版信息
Br J Pharmacol. 1974 Feb;50(2):291-7. doi: 10.1111/j.1476-5381.1974.tb08575.x.
Abstract
1 The dose-response curves for angiotensin II and four analogues in rat colon and uterus, and in rabbit aorta, were obtained.2 The ED(50) values of angiotensin II as well as the ED(50)s and intrinsic activities of angiotensin analogues varied between the three organs.3 The interaction of two competitive antagonists with angiotensin II receptors was also examined. The K(I) values obtained with both antagonists on the uterus differed from the values on the other tissues.4 It is concluded that angiotensin II receptors may be different in the three organs examined.
摘要
获得了血管紧张素II及其四种类似物在大鼠结肠和子宫以及兔主动脉中的剂量 - 反应曲线。
血管紧张素II的半数有效剂量（ED50）值以及血管紧张素类似物的ED50值和内在活性在这三种器官中有所不同。
还研究了两种竞争性拮抗剂与血管紧张素II受体的相互作用。两种拮抗剂在子宫上获得的抑制常数（K(I)）值与在其他组织上的值不同。
得出的结论是，在所研究的三种器官中，血管紧张素II受体可能不同。
相似文献
1
Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle: existence of different forms of receptor sites for angiotensin II.三种类型平滑肌中血管紧张素II及合成类似物的剂量反应曲线：血管紧张素II不同形式受体位点的存在
Br J Pharmacol. 1974 Feb;50(2):291-7. doi: 10.1111/j.1476-5381.1974.tb08575.x.
2
Specific supersensitivity of smooth muscle to angiotensin II after nephrectomy.肾切除术后平滑肌对血管紧张素II的特异性超敏反应。
Br J Pharmacol. 1974 Jul;51(3):435-9. doi: 10.1111/j.1476-5381.1974.tb10679.x.
3
Characterization of angiotensin receptors in vascular and intestinal smooth muscles.血管和肠道平滑肌中血管紧张素受体的特征
Br J Pharmacol. 1973 Jun;48(2):288-301. doi: 10.1111/j.1476-5381.1973.tb06915.x.
4
Characterization of smooth muscle receptors for angiotensin: studies with an antagonist.
Am J Physiol. 1974 Jan;226(1):185-90. doi: 10.1152/ajplegacy.1974.226.1.185.
5
A comparison of the effects of angiotensin II and heptapeptide on smooth muscle (vascular and uterine).
Eur J Pharmacol. 1976 Sep;39(1):101-7. doi: 10.1016/0014-2999(76)90117-5.
6
Application of drug-receptor theories to angiotensin.药物-受体理论在血管紧张素中的应用。
Can J Physiol Pharmacol. 1973 Sep;51(9):665-72. doi: 10.1139/y73-100.
7
Comparison of angiotensin receptors in isolated smooth muscle tissues by photoaffinity labelling.通过光亲和标记法对分离的平滑肌组织中的血管紧张素受体进行比较。
Eur J Pharmacol. 1985 Sep 10;115(1):53-8. doi: 10.1016/0014-2999(85)90583-7.
8
Angiotensin-receptor interaction: influence of pH on angiotensin inhibition by Phe 4 -Tyr 8 -angiotensin II in rat uterine smooth muscle.
Arch Int Pharmacodyn Ther. 1972 Nov;200(1):118-25.
9
Calcium and angiotensin tachyphylaxis in rat uterine smooth muscle.大鼠子宫平滑肌中的钙与血管紧张素快速耐受性
Am J Physiol. 1975 May;228(5):1423-30. doi: 10.1152/ajplegacy.1975.228.5.1423.
10
Classification of angiotensin receptors in rat isolated uterus, portal vein, and aorta with the novel competitive antagonist sarmesin.
Pharmacology. 1988;37(3):137-47. doi: 10.1159/000138457.
引用本文的文献
1
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34.血管紧张素受体信号激活、配体选择性和变构调节机制的结构观点：国际药理学联合会评论 34。
Br J Pharmacol. 2022 Sep;179(18):4461-4472. doi: 10.1111/bph.15840. Epub 2022 Apr 23.
2
Comparative effects of angiotensin II and its degradation products angiotensin III and angiotensin IV in rat aorta.血管紧张素II及其降解产物血管紧张素III和血管紧张素IV对大鼠主动脉的比较作用。
Br J Pharmacol. 1995 Dec;116(7):2963-70. doi: 10.1111/j.1476-5381.1995.tb15951.x.
3
Receptors: the materialization of a concept.受体：一个概念的具体体现。
Pharm Weekbl Sci. 1983 Aug 26;5(4):121-8. doi: 10.1007/BF01961466.
4
Identification of the angiotensin II receptor in rat mesenteric artery.大鼠肠系膜动脉中血管紧张素II受体的鉴定。
Biochem J. 1984 Nov 1;223(3):659-71. doi: 10.1042/bj2230659.
5
Specific supersensitivity of smooth muscle to angiotensin II after nephrectomy.肾切除术后平滑肌对血管紧张素II的特异性超敏反应。
Br J Pharmacol. 1974 Jul;51(3):435-9. doi: 10.1111/j.1476-5381.1974.tb10679.x.
本文引用的文献
1
Drug antagonism and pAx.药物拮抗作用与pAx
Pharmacol Rev. 1957 Jun;9(2):242-6.
2
A modification of receptor theory.受体理论的一种修正。
Br J Pharmacol Chemother. 1956 Dec;11(4):379-93. doi: 10.1111/j.1476-5381.1956.tb00006.x.
3
Receptor occupancy and tissue response.受体占有率与组织反应。
Nature. 1956 Sep 29;178(4535):697-8. doi: 10.1038/178697b0.
4
Affinity and intrinsic-activity in the theory of competitive inhibition. III. Homologous decamethonium-derivatives and succinyl-choline-esters.竞争性抑制理论中的亲和力与内在活性。III. 同源十烃季铵衍生物和琥珀酰胆碱酯类
Arch Int Pharmacodyn Ther. 1954 Sep 15;99(2):193-205.
5
Pharmacological receptors.药理受体
Pharmacol Rev. 1968 Jun;20(2):49-88.
6
The pressor and myotropic effects and the antagonistic properties of several analogues of angiotensin II.血管紧张素II几种类似物的升压、对肌性组织的作用及拮抗特性。
Can J Physiol Pharmacol. 1972 Feb;50(2):99-112. doi: 10.1139/y72-016.
7
Competative antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat colon.
Eur J Pharmacol. 1971;15(3):285-91. doi: 10.1016/0014-2999(71)90094-x.
8
Release of adrenal catecholamines by angiotensin I.血管紧张素I对肾上腺儿茶酚胺的释放作用。
J Pharmacol Exp Ther. 1971 Feb;176(2):366-76.
9
Possible existence of different types of angiotensin II receptors.不同类型血管紧张素II受体的可能存在。
Br J Pharmacol. 1970 Nov;40(3):541P-542P.
Zotero 插件