三种类型平滑肌中血管紧张素II及合成类似物的剂量反应曲线：血管紧张素II不同形式受体位点的存在
Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle: existence of different forms of receptor sites for angiotensin II.
作者信息
Papadimitriou A, Worcel M
出版信息
Br J Pharmacol. 1974 Feb;50(2):291-7. doi: 10.1111/j.1476-5381.1974.tb08575.x.
Abstract
1 The dose-response curves for angiotensin II and four analogues in rat colon and uterus, and in rabbit aorta, were obtained.2 The ED(50) values of angiotensin II as well as the ED(50)s and intrinsic activities of angiotensin analogues varied between the three organs.3 The interaction of two competitive antagonists with angiotensin II receptors was also examined. The K(I) values obtained with both antagonists on the uterus differed from the values on the other tissues.4 It is concluded that angiotensin II receptors may be different in the three organs examined.
摘要
获得了血管紧张素II及其四种类似物在大鼠结肠和子宫以及兔主动脉中的剂量 - 反应曲线。
血管紧张素II的半数有效剂量（ED50）值以及血管紧张素类似物的ED50值和内在活性在这三种器官中有所不同。
还研究了两种竞争性拮抗剂与血管紧张素II受体的相互作用。两种拮抗剂在子宫上获得的抑制常数（K(I)）值与在其他组织上的值不同。
得出的结论是，在所研究的三种器官中，血管紧张素II受体可能不同。
相似文献
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Dose-response curves for angiotensin II and synthetic analogues in three types of smooth muscle: existence of different forms of receptor sites for angiotensin II.三种类型平滑肌中血管紧张素II及合成类似物的剂量反应曲线：血管紧张素II不同形式受体位点的存在
Br J Pharmacol. 1974 Feb;50(2):291-7. doi: 10.1111/j.1476-5381.1974.tb08575.x.
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5
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