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3':5'-环磷酸腺苷的抗合成代谢作用。对蛋白质合成的抑制。

Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis.

作者信息

Sellers A, Bloxham D P, Munday K A, Akhtar M

出版信息

Biochem J. 1974 Mar;138(3):335-40. doi: 10.1042/bj1380335.

DOI:10.1042/bj1380335
PMID:4372990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166218/
Abstract
  1. Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-(3)H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.
摘要
  1. 有证据表明，环磷酸腺苷（cyclic AMP）在大鼠肝脏的无细胞体系中会抑制l-[4,5-(3)H]亮氨酸掺入蛋白质中。这种抑制作用发生在氨酰基-tRNA形成之后。2. 线粒体后上清液与环磷酸腺苷和三磷酸腺苷（ATP）一起孵育后分离得到的微粒体部分，其合成蛋白质的能力减弱。环磷酸腺苷和三磷酸腺苷对此效应均是必需的。3. 从糖异生的控制方面讨论了环磷酸腺苷抗合成代谢作用可能的生理作用。

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引用本文的文献

1
Enhancement of the anti-anabolic response to adenosine 3':5'-cyclic monophosphate during development. The inhibition of hepatic protein synthesis.发育过程中对3':5'-环磷酸腺苷抗合成代谢反应的增强。肝脏蛋白质合成的抑制。
Biochem J. 1977 Nov 15;168(2):271-5. doi: 10.1042/bj1680271.
2
Mechanism of translational control by hemin in reticulocyte lysates.血红素对网织红细胞裂解物翻译控制的机制。
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3326-9. doi: 10.1073/pnas.74.8.3326.
3
Growth hormone, cyclic nucleotides and the rapid control of translation in heart muscle.生长激素、环核苷酸与心肌翻译的快速调控
Biochem J. 1975 Dec;152(3):583-92. doi: 10.1042/bj1520583.

本文引用的文献

1
Biosynthesis of labeled fatty acids and cholesterol in experimental diabetes.实验性糖尿病中标记脂肪酸和胆固醇的生物合成
J Biol Chem. 1950 Dec;187(2):589-96.
2
Studies on carbohydrate metabolism in rat liver slices. IV. Biochemical sequence of events after insulin administration.大鼠肝切片碳水化合物代谢的研究。IV. 注射胰岛素后事件的生化序列。
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Phosphorylation of some rat liver ribosomal proteins and its activation by cyclic AMP.大鼠肝脏核糖体蛋白的磷酸化及其被环磷酸腺苷激活的过程
FEBS Lett. 1970 Sep 24;10(2):105-108. doi: 10.1016/0014-5793(70)80427-6.
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Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.3',5'-环磷酸腺苷在胰岛素及抗胰岛素血清对肝脏代谢影响中的作用
J Biol Chem. 1968 Mar 10;243(5):1031-8.
9
Control of protein synthesis in mammalian tissues through changes in ribosome activity.通过核糖体活性的变化来控制哺乳动物组织中的蛋白质合成。
J Biol Chem. 1971 Jan 25;246(2):436-46.
10
Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.胆固醇生物合成中C-4去甲基化的机制与调控研究。3':5'-环磷酸腺苷的作用。
Biochem J. 1971 Nov;125(2):625-34. doi: 10.1042/bj1250625.