3':5'-环磷酸腺苷的抗合成代谢作用。对蛋白质合成的抑制。
Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis.
作者信息
Sellers A, Bloxham D P, Munday K A, Akhtar M
出版信息
Biochem J. 1974 Mar;138(3):335-40. doi: 10.1042/bj1380335.
Abstract
- Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-(3)H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.
摘要
- 有证据表明，环磷酸腺苷（cyclic AMP）在大鼠肝脏的无细胞体系中会抑制l-[4,5-(3)H]亮氨酸掺入蛋白质中。这种抑制作用发生在氨酰基-tRNA形成之后。2. 线粒体后上清液与环磷酸腺苷和三磷酸腺苷（ATP）一起孵育后分离得到的微粒体部分，其合成蛋白质的能力减弱。环磷酸腺苷和三磷酸腺苷对此效应均是必需的。3. 从糖异生的控制方面讨论了环磷酸腺苷抗合成代谢作用可能的生理作用。
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